Tyrosine Kinase Inhibitors and Male Reproductive Health.

Tyrosine Kinase Inhibitors and Male Reproductive Health.
Clin Pharmacol Ther. 2017 Nov;102(5):754-756
Authors: Ramstein JJ, Tsai KK, Smith JF
Abstract
Tyrosine kinase inhibitors (TKIs) are a targeted class of cancer therapies effective against a range of malignancies and their use is growing significantly each year. Many men taking TKIs desire children, yet very little is known about the potential for reproductive harm of these medications. The mechanism of action of TKIs suggest a possible route to impairment of sperm functional properties or spermatogenesis.
PMID: 28791688 [PubMed - indexed for MEDLINE]

Source: Clinical Pharmacology and Therapeutics - October 22, 2017 Category: Drugs & Pharmacology Authors: Ramstein JJ, Tsai KK, Smith JF Tags: Clin Pharmacol Ther Source Type: research