ACG Wrap-up: Fecal Transplant; Lynch Syndrome Screening; Probiotics for Pain

(MedPage Today) -- Additional highlights from this year's meeting
Source: MedPage Today Gastroenterology - Category: Gastroenterology Source Type: news

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Conclusions: I-131 MIBG therapy can be used as a neoadjuvant therapy to reduce tumor mass and size, and thus is also a first line treatment. Both our patients had an improvement in their functional aspect of life and also had no hypertensive crises or tumor lysis syndrome even though both had a large tumor burden. Thus we conclude that I-131 MIBG is a safe therapy and should be considered preoperatively to reduce tumor size if it is needed. MIBG therapy can be used as a neoadjuvant therapy to reduce tumor mass and size, and thus is also a first line treatment.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Endocrine/Neuroendocrine (Therapy/Non-Therapy) Poster Session Source Type: research
AbstractTo prevent endometrial carcinoma in Lynch syndrome (LS), regular gynecological surveillance visits and prophylactic surgery are recommended. Previous data have shown that prophylactic hysterectomy is an effective means of cancer prevention, while the advantages and disadvantages of surveillance are somewhat unclear. We aimed to evaluate female LS carriers ’ attitudes towards regular gynecological surveillance and factors influencing their decision-making on prophylactic surgery that have not been well documented. Pain experienced during endometrial biopsies was also evaluated. Postal questionnaires were sent ...
Source: Familial Cancer - Category: Cancer & Oncology Source Type: research
CONCLUSIONWhen detecting a lytic spinal tumor in a patient who suffers from LS a SPB should be taken under consideration.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
A 63-year-old female with known history of Lynch Syndrome with MSH2 gene deletion presented to the emergency department with left flank and epigastric pain worsening over one week. She had a three-year history of intermittent gross hematuria, with no masses or hydronephrosis on non-contrast abdominal and pelvic CT scan 2.5 years prior. Review of systems was otherwise negative. Patient reported previously negative evaluation with cystoscopy and repeat urinalysis for gross hematuria by outside urologist.
Source: Urology - Category: Urology & Nephrology Authors: Source Type: research
We present the case of a 68-year-old male with a confirmed diagnosis of Lynch syndrome secondary to a germlineMSH2 mismatch-repair gene-mutation who presented with 2  months history of non-specific abdominal pain. After imaging work-up, the patient was found to have a right upper quadrant, retroperitoneal mass. Biochemical tests were without any evidence of a hormonally active process. Fine needle aspiration of the mass revealed a poorly differentiated carcinom a of unknown etiology. The lesion was resected and found to be consistent with ectopic ACC with an associatedMSH2 mutation.
Source: Familial Cancer - Category: Cancer & Oncology Source Type: research
We present a 59 year-old female with Lynch Syndrome and a 3 cm low-grade UTUC in the right mid ureter on a CT scan for abdominal pain. Patient elected for segmental ureterectomy with a buccal mucosa graft reconstruction due to location of the tumor and risk of bilateral disease.
Source: The Journal of Urology - Category: Urology & Nephrology Authors: Tags: Reconstruction - Upper Urinary Tract Source Type: research
Question: A 62-year-old female with Lynch syndrome had a CT scan performed after a fall, which incidentally discovered multiple polypoid lesions within the stomach. The patient had a history of endometrial adenocarcinoma at age 50, as well as a family history significant for a sister with colon cancer at age 59. Based on this cancer history she had recently undergone genetic testing which revealed a pathogenic PMS2 mutation, consistent with Lynch syndrome. The patient was asymptomatic from a gastrointestinal perspective without any nausea, vomiting, abdominal pain, diarrhea, rectal bleeding, or unintentional weight loss.
Source: Gastroenterology - Category: Gastroenterology Authors: Tags: Practical Teaching Cases Source Type: research
We present an unusual pediatric case of invasive upper tract urothelial carcinoma with an associated genetic predisposition. A 14-year-old female presented with intermittent right flank pain, and was found to have a poorly functioning hydronephrotic right kidney. Laparoscopic nephrectomy was performed. Pathology demonstrated upper tract urothelial carcinoma, and she subsequently underwent completion ureterectomy. Genetic studies demonstrated a double-hit constitutional deletion of a DNA mismatch repair protein, revealing a rare Lynch syndrome variant known as Constitutional Mismatch Repair Deficiency Syndrome.
Source: Urology - Category: Urology & Nephrology Authors: Tags: Pediatric Case Reports Source Type: research
We present an unusual pediatric case of invasive upper tract urothelial carcinoma with an associated genetic predisposition. A 14 year-old female presented with intermittent right flank pain, and was found to have a poorly functioning hydronephrotic right kidney. Laparoscopic nephrectomy was performed. Pathology demonstrated upper tract urothelial carcinoma, and she subsequently underwent completion ureterectomy. Genetic studies demonstrated a double-hit constitutional deletion of a DNA mismatch repair protein, revealing a rare Lynch syndrome variant known as Constitutional Mismatch Repair Deficiency Syndrome (CMMRD).
Source: Urology - Category: Urology & Nephrology Authors: Tags: Pediatric Case Reports Source Type: research
Michelle Chi: I Have No Relevant Financial Relationships To Disclose
Source: PM and R - Category: Rehabilitation Authors: Source Type: research
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