Germinal center B cells are essential for collagen ‐induced arthritis

ConclusionTogether, we identify germinal center formation and anti‐collagen antibody production as the key pathogenic function of B cells in CIA. The role of B cells in RA is likely to be more complex. However, targeting the germinal center reaction could allow for more refined therapeutic interventions than general B cell depletion.This article is protected by copyright. All rights reserved.

Source: Arthritis and Rheumatism - October 17, 2017 Category: Rheumatology Authors: Albert Dahdah, Katrin Habir, Kutty Selva Nandakumar, Amit Saxena, Bingze Xu, Rikard Holmdahl, Stephen Malin Tags: Full Length Source Type: research