Rickettsial retinitis: Direct bacterial infection or an immune-mediated response ?

We report such a case of bilateral rickettsial retinitis proven by serology which worsened on systemic steroids and responded dramatically to therapy with oral doxycycline and steroid taper. We thus believe that direct bacterial invasion plays a major role in the pathogenesis of rickettsial retinitis.
Source: Indian Journal of Ophthalmology - Category: Opthalmology Authors: Source Type: research

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Conclusions: TMP alleviates morphological and functional retinal damage in mice exposed to NaIO3 and reduces retinal apoptosis. PMID: 32636604 [PubMed - in process]
Source: Molecular Vision - Category: Molecular Biology Tags: Mol Vis Source Type: research
We report the results of gene expression profiling via RNA-sequencing of primary human choroid plexus epithelial cells in vitro that were infected with Borrelia burgdorferi, the causative agent of Lyme disease. Epithelial cells were cultured with B. burgdorferi for 48 hours prior to RNA isolation. Following high-throughput sequencing via Illumina HiSeq 4000, a total of 258 differentially expressed genes were identified. Subsequent data analysis indicates an inflammatory and immune response generated by the epithelial cells following infection, marked by chemotactic cytokines and interferon stimulated genes. Several genes a...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
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Source: Clinical Epidemiology and Global Health - Category: Epidemiology Source Type: research
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Source: NYT Health - Category: Consumer Health News Tags: Coronavirus (2019-nCoV) Source Type: news
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Source: Medical Journal Armed Forces India - Category: General Medicine Source Type: research
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Source: Medical Journal Armed Forces India - Category: General Medicine Source Type: research
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Source: Medical Journal Armed Forces India - Category: General Medicine Source Type: research
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Source: Medical Journal Armed Forces India - Category: General Medicine Source Type: research
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Source: Medical Journal Armed Forces India - Category: General Medicine Source Type: research
Source: Infection and Drug Resistance - Category: Infectious Diseases Tags: Infection and Drug Resistance Source Type: research
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