Hot News: Exosomes as New Players in HIV Pathogenesis - New Data from the IAS 2017.

Hot News: Exosomes as New Players in HIV Pathogenesis - New Data from the IAS 2017. AIDS Rev. 2017 Oct 11;19(3) Authors: Poveda E, Freeman ML Abstract Exosomes are nanovesicles that can be released into the extracellular medium by different cell types and are considered an important system of intercellular communication. In some instances, on secretion, exosomes break down and release their content into the extracellular space. Alternatively, intact exosomes can interact with other cells and discharge their content directly into the target cell cytoplasm. Exosomes are rich in endosome-associated proteins (i.e., the tetraspanin family) but also carry different molecules in their lumen including proteins, RNAs (i.e., microRNAs), and pathogenderived cargo. Indeed, the different biological functions of exosomes might depend on their cargo components. Several recent publications have identified exosomes as new players in the pathogenesis of HIV infection. This is an emerging field of growing interest that deserved a satellite symposium at the 9th IAS Conference held in Paris in July 2017, sponsored by the International Society for Extracellular Vesicles (EVs). Although the role of exosomes in HIV infection is not yet clarified, accumulating data suggest that exosomes may act at different levels of HIV pathogenesis by modulating immune responses, infectivity, or even by activating the latent viral reservoir. However, there are still method...
Source: AIDS Reviews - Category: Infectious Diseases Authors: Tags: AIDS Rev Source Type: research