Researchers find mechanism involved in novel drug design with potential to treat tuberculosis

(Instituto de Medicina Molecular) Portuguese researchers successfully used a pioneer method to chemically modify a protein's components with potential medical applications and an impact in the fight against tuberculosis.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news

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Authors: Li W, Deng W, Xie J Abstract Tuberculosis, caused by Mycobacterium tuberculosis, remains a leading cause of morbidity and mortality globally, with nearly 10.4 million new cases of incidence and over 1.7 million deaths annually. Drug-resistant M. tuberculosis strains, especially multidrug-resistant or extensively drug-resistant strains, have further intensified the problem associated with tuberculosis control. Host-directed therapy is a promising alternative for tuberculosis control. IL-32 is increasingly recognized as an important host molecule against tuberculosis. In this review, we highlight the proinfl...
Source: Journal of Immunology Research - Category: Allergy & Immunology Tags: J Immunol Res Source Type: research
Publication date: Available online 15 November 2018Source: Journal of Molecular StructureAuthor(s): M.R. Maliyappa, J. Keshavayya, N.M. Mallikarjuna, P. Murali Krishna, N. Shivakumara, Telkar Sandeep, Krishnamurty Sailaja, Mohammed Azeezulla NazrullaAbstractThe present work describes the synthesis of five novel heterocyclic azo dyes (4a-4e) through conventional diazo-coupling reaction of 4, 5, 6, 7-tetrahydro-1, 3-benzothiazole with various coupling compounds at 0–5 °C. The chemical structures of the synthesized azo dyes were characterized by both theoretical and experimental techniques. All the synthesized mol...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
In this study, the MVA pathway was engineered in Escherichia coli to biosynthesis of the antimycobacterial agent geranylgeranyl acetate from glucose for the first time. Three modules were constructed in E. coli to achieve this objective. AtoB, ERG13 and tHMG1 were overexpressed in the upstream module to accumulate MVA. Then MVA were catalyzed to IPP and DMAPP in the midstream module, which overexpressed Idi, ERG8, MVD1 and ERG12. Finally, in the downstream module, geranylgeranyl acetate were biosynthesized from IPP and DMAPP by overexpressing GGPPS, PgpB and ATF1. The engineered strain DG108 accumulated 57 ±&...
Source: Biochemical Engineering Journal - Category: Biochemistry Source Type: research
ConclusionsTST and IGRA have a low agreement. Both tests should be included in the strategy to diagnose LTBI prior to biologic therapy in IMID patients.
Source: The Egyptian Rheumatologist - Category: Rheumatology Source Type: research
Health experts: North Korea is facing shortage of tuberculosis medications that could accelerate spread of more deadly strain, putting hundreds of thousands at risk
Source: ABC News: Health - Category: Consumer Health News Tags: Health Source Type: news
[Nation] The country has run out of cartridges used for printing out results for tuberculosis (TB) patients in public hospitals.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
A U.S.-based nonprofit group has called for South Korea to take stronger steps to fight a tuberculosis crisis in North Korea it says has worsened under strengthened U.S.-led sanctions against the country over its nuclear weapons and missile program
Source: ABC News: Health - Category: Consumer Health News Tags: Health Source Type: news
HowMycobacterium tuberculosis (Mtb) rewires macrophage energy metabolism to facilitate survival is poorly characterized. Here, we used extracellular flux analysis to simultaneously measure the rates of glycolysis and respiration in real-time.Mtb infection induced a quiescent energy phenotype in human monocyte-derived macrophages and decelerated flux through glycolysis and the TCA cycle. In contrast, infection with the vaccine strain,M.bovis BCG, or deadMtb induced glycolytic phenotypes with greater flux. Furthermore,Mtbreduced the mitochondrial dependency on glucose and increased the mitochondrial dependency on fatty acids...
Source: eLife - Category: Biomedical Science Tags: Biochemistry and Chemical Biology Microbiology and Infectious Disease Source Type: research
Publication date: Available online 14 November 2018Source: International Journal of Africa Nursing SciencesAuthor(s): Sotah Mahanya, Mduduzi Shongwe, Dumsile MshayisaAbstractBackgroundTuberculosis is major cause of death worldwide and Swaziland is one of the countries with highest rates. The fear of drug resistant tuberculosis among nurses may lead to poor nurse caring behaviors which patient perceive as stigma.ObjectivesTo examine (1) the relationship between patients’ perceptions of nurse caring and tuberculosis stigma; (2) the predictors of tuberculosis related stigma among patients with drug resistant TB in Swazi...
Source: International Journal of Africa Nursing Sciences - Category: African Health Source Type: research
Publication date: Available online 14 November 2018Source: Spatial and Spatio-temporal EpidemiologyAuthor(s): G.M. Milne, J. Graham, A. Allen, A. Lahuerta-Marin, C. McCormick, E. Presho, R. Skuce, A.W. ByrneAbstractDespite a state-led eradication programme, bovine tuberculosis (bTB) remains endemic in Northern Ireland (NI). Of particular concern are “chronic” prolonged and recurrent bTB breakdowns, which represent significant financial and administrative burdens. However, little is known regarding the spatiotemporal distribution of chronic breakdowns in NI. We therefore analysed both the spatial and spatiotempo...
Source: Spatial and Spatio-temporal Epidemiology - Category: Epidemiology Source Type: research
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