Researchers find mechanism involved in novel drug design with potential to treat tuberculosis

(Instituto de Medicina Molecular) Portuguese researchers successfully used a pioneer method to chemically modify a protein's components with potential medical applications and an impact in the fight against tuberculosis.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news

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ABSTRACT Acute pulmonary thromboembolism (APTE) is a highly prevalent condition (104-183 cases per 100,000 person-years) and is potentially fatal. Approximately 20% of patients with APTE are hypotensive, being considered at high risk of death. In such patients, immediate lung reperfusion is necessary in order to reduce right ventricular afterload and to restore hemodynamic stability. To reduce pulmonary vascular resistance in APTE and, consequently, to improve right ventricular function, lung reperfusion strategies have been developed over time and widely studied in recent years. In this review, we focus on advances in the...
Source: Jornal Brasileiro de Pneumologia - Category: Respiratory Medicine Source Type: research
This study profiles TB-related acute care hospitalizations among new immigrants to Canada by selected characteristics. DATA AND METHODS: This study is based on the 2000-to-2013 Longitudinal Immigration Database (IMDB) linked to the Canadian Institute for Health Information's Discharge Abstract Database (DAD) from 2001/2002 to 2013/2014. It examines the timing of first TB-related acute care hospitalization occurring from the fiscal year 2001/2002 to the fiscal year 2013/2014 among immigrants who landed in Canada from 2000 to 2013 outside of Quebec and the territories. Mean and median hospital days and the percentage of ...
Source: Health Reports - Category: International Medicine & Public Health Tags: Health Rep Source Type: research
Inmates at the National Penitentiary in Port-au-Prince, Haiti. Credit: David BrydenBy David BrydenWASHINGTON DC, Jul 19 2018 (IPS)Dozens of grown men peered from behind the barred doorway of a crammed window-less prison cell, eyes pleading desperately from sweaty faces.Their physical discomfort was so palpable, I could almost feel it. Because of my work, I also knew of at least one serious unseen risk facing them – that of contracting tuberculosis in the cramped, poorly ventilated space. Touring the largest prison in Port-au-Prince was part of a research visit I made there in 2106. Two years later, the image of those...
Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: Development & Aid Featured Global Headlines Health Population Poverty & SDGs TerraViva United Nations Source Type: news
We report a case of late-onset DILI occurring after 11 months of isavuconazole therapy in a 55-year old man of Angolan descent on long-term antifungal therapy for the management of chronic pulmonary aspergillosis complicating previously treated pulmonary tuberculosis. The DILI could be described as idiosyncratic as it was not associated with high isavuconazole serum levels and his liver function tests returned to normal following treatment discontinuation.
Source: Medical Mycology Case Reports - Category: Biology Source Type: research
CONCLUSION: Among patients presenting with miliary TB who underwent brain imaging, more than 60% demonstrated cerebral involvement. Abnormal imaging could occur without any clinical nor CSF impairment. Systematically performing brain imaging in miliary TB patients could therefore be informative. PMID: 30017477 [PubMed - as supplied by publisher]
Source: Medecine et Maladies Infectieuses - Category: Infectious Diseases Tags: Med Mal Infect Source Type: research
Sjögren's and plasma cell variant Castleman disease: a case report. Ghana Med J. 2018 Mar;52(1):61-65 Authors: Dei-Adomakoh YA, Quarcoopome L, Abrahams AD, Segbefia CI, Dey DI Abstract Castleman disease is a rare cause of lymphoid hyperplasia and may result in localized symptoms or an aggressive, multisystem disorder. It can mimic other diseases like lymphoma or tuberculosis. It classically presents as a mediastinal mass that involves the lymphatic tissue primarily but can also affect extra lymphatic sites including the lungs, larynx, parotid glands, pancreas, meninges, and muscles. In HIV and HHV...
Source: Ghana Medical Journal - Category: African Health Tags: Ghana Med J Source Type: research
amavati Tuberculosis (TB) is caused by Mycobacterium tuberculosis (MTB) and transmitted through inhalation of aerosolized droplets. Eighty-five percent of new TB cases occur in resource-limited countries in Asia and Africa and fewer than 40% of TB cases are diagnosed due to the lack of accurate and easy-to-use diagnostic assays. Currently, diagnosis relies on the demonstration of the bacterium in clinical specimens by serial sputum smear microscopy and culture. These methods lack sensitivity, are time consuming, expensive, and require trained personnel. An alternative approach is to develop an efficient immunoassay to ...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
ConclusionATB has varied radiological features; however, peritoneal involvement in the form of mild ascites, smooth peritoneal thickening, smudgy omentum, multi-focal bowel involvement, necrotic nodes, and multiple visceral microabscesses point towards a diagnosis of ATB in appropriate clinical setting.
Source: Abdominal Imaging - Category: Radiology Source Type: research
Xiao-bo Wang, Xue-lian Li, Qing Zhang, Juan Zhang, Hong-yan Chen, Wei-yuan Xu, Ying-hui Fu, Qiu-yue Wang, Jian Kang, Gang Hou
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Tuberculosis (TB) caused by strains of Mycobacterium tuberculosis that are rifampicin-resistant (RR), multidrug-resistant (MDR) (strains resistant to at least isoniazid and rifampicin) or extensively drug-resistant (XDR) (MDR strains resistant to any fluoroquinolone (FQ) and to at least one second-line injectable drug (SLID): kanamycin, capreomycin or amikacin) is a major threat to TB control globally. All three groups require treatment with second-line drugs (SLDs) [1]. We previously reported that MDR- and XDR-TB in Italy occurred mostly in foreign-born persons (FBPs) [2, 3], but no major information on RR, MDR or XDR tre...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Original Articles: Research letters Source Type: research
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