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Researchers find mechanism involved in novel drug design with potential to treat tuberculosis

(Instituto de Medicina Molecular) Portuguese researchers successfully used a pioneer method to chemically modify a protein's components with potential medical applications and an impact in the fight against tuberculosis.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news

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Seventeen cases of tuberculosis were recorded in Allegheny County last year.
Source: bizjournals.com Health Care:Pharmaceuticals headlines - Category: Pharmaceuticals Authors: Source Type: news
UPMC said Friday a UPMC Presbyterian ER employee developed tuberculosis and the system is notifying and testing patients and staff who may have come in contact with the employee. The employee of the Presby emergency department, who was not identified, is on medical leave and recovering at home. UPMC said the employee had also been a patient at a doctor’s office at Magee-Womens Hospital of UPMC and the ophthalmology clinic at Presby. Tuberculosis is an airborne disease c aused by bacteria that…
Source: bizjournals.com Health Care:Physician Practices headlines - Category: American Health Authors: Source Type: news
AbstractTo determine, among systemic lupus erythematosus patients, factors associated with active tuberculosis. We performed a case-control study, in a tertiary-care center in Mexico City. We defined cases as systemic lupus erythematosus patients with active tuberculosis and matched them 1:1 with systemic lupus erythematosus patients without tuberculosis (controls) by age, date of systemic lupus erythematosus diagnosis, and disease duration. We analyzed clinical variables, lupus disease activity (SLEDAI-2K), and accumulated damage (SLICC/ARC-DI). We performed a nonconditional logistic regression to determine factors associ...
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
Publication date: Available online 19 April 2018 Source:The Brazilian Journal of Infectious Diseases Author(s): Suzana Batista Vereza de Oliveira, Ângelo Ferreira Passos, David Jamil Hadad, Lorena Zbyszynski, Pedro Sousa de Almeida Júnior, Luiz Guilherme Schmidt Castellani, Reynaldo Dietze, Moisés Palaci Tuberculosis (TB) is an infectious disease of global importance with major economic and social burden accounting for 25% of all avoidable deaths in developing countries. Extrapulmonary involvement may occur either in association with clinically apparent pulmonary tuberculosis or in isolation. This cros...
Source: The Brazilian Journal of Infectious Diseases - Category: Infectious Diseases Source Type: research
AbstractThe role of metformin (MET) on treatment effect of diabetic tuberculosis (TB) patients has not been studied in China. Thus, we conducted a retrospective study to investigate whether MET exhibited more efficacy in combination with anti-TB regimens for diabetic TB patients. All patients recruited came from five tuberculosis control and prevention institutes from July 2009 to July 2016 and completed 3  years of follow-up. We used chi-square test or Fisher’s exact test to evaluate the demographic characteristics and the frequency of clinical outcome between MET and non-MET group. A total of 58 TB patients wi...
Source: European Journal of Clinical Microbiology and Infectious Diseases - Category: Microbiology Source Type: research
AbstractTuberculosis (TB) remains one of the most deadly infections with approximately a quarter of cases not being identified and/or treated mainly due to a lack of resources. Rapid detection of TB or drug-resistant TB enables timely adequate treatment and is a cornerstone of effective TB management. We evaluated the analytical performance of a single-tube assay for multidrug-resistant TB (MDR-TB) on an experimental platform utilising RT-PCR and melting curve analysis that could potentially be operated as a point-of-care (PoC) test in resource-constrained settings with a high burden of TB. Firstly, we developed and evalua...
Source: European Journal of Clinical Microbiology and Infectious Diseases - Category: Microbiology Source Type: research
The Global Fund's decision to withdraw from North Korea is jeopardising tuberculosis control in the country. Talha Burki reports.
Source: The Lancet Infectious Diseases - Category: Infectious Diseases Authors: Tags: Newsdesk Source Type: research
Conclusion: Evidence for optimal treatment options for HIV/TB coinfected children is limited. As the global community strives to reach the fast-track HIV treatment targets and eliminate childhood TB deaths, it must ensure that coinfected children are included in key treatment studies and expand this neglected but crucial area of research.
Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: HIV Reports Source Type: research
Conclusions: Our findings demonstrate an association between polymorphisms in IL6 and IL10 and risk of PTB. PMID: 29662655 [PubMed]
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
[Prevalence and risk factors associated to tuberculosis and non-tuberculous mycobacterial infections in HIV-positive patients in Bogotá]. Biomedica. 2018 Mar 15;38(1):120-127 Authors: Beltrán-León M, Pérez-Llanos F, Sánchez L, Parra-López C, Navarrete M, Sánchez R, Awad C, Granada AM, Quintero E, Briceño Ó, Cruz Ó, Murcia MI Abstract INTRODUCTION: Tuberculosis is one of the most widely distributed infectious diseases worldwide. It is the most common cause of mortality among AIDS patients. In Colombia, 12,918 tuberculosis cases were n...
Source: Biomedica : Revista del Instituto Nacional de Salud - Category: International Medicine & Public Health Tags: Biomedica Source Type: research
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