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In Vitro and In Vivo Activity of a Novel Antifungal Small Molecule against Candida Infections

Candida is the most common fungal pathogen of humans worldwide and has become a major clinical problem because of the growing number of immunocompromised patients, who are susceptible to infection. Moreover, the number of available antifungals is limited, and antifungal-resistantCandida strains are emerging. New and effective antifungals are therefore urgently needed. Here, we discovered a small molecule with activity againstCandida spp. bothin vitro andin vivo.
Source: The Aspergillus Website - updates - Category: Respiratory Medicine Authors: Source Type: news

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Authors: Saif MJ, Zuber M, Anwar J, Munawar MA Abstract The antimicrobial activity of two new series of bis-piperidinium compounds with alkyl chains of different lengths against bacterial (Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Bacillus subtilis) and fungal strains (Aspergillus flavus, Aspergillus niger, Rhodolorula rubera, Lipomyces lopofera and Candida albicans), are described. Antimicrobial activities of the synthesized compounds were compared to that of dodecyltrimethylammonium chloride. Bis-piperidinium salts possessing 12-16 carbon side chains showed better antimicrobial propertie...
Source: Polish Journal of Microbiology - Category: Microbiology Tags: Pol J Microbiol Source Type: research
Conclusion: The essential oil showed moderate antioxidant activity, strong antimicrobial properties and good toxic effect in brine shrimp test and MTT assay on three cancerous cell lines. PMID: 29322058 [PubMed]
Source: Iranian Journal of Arthropod-Borne Diseases - Category: Infectious Diseases Tags: J Arthropod Borne Dis Source Type: research
This article is protected by copyright. All rights reserved. PMID: 29315506 [PubMed - as supplied by publisher]
Source: Clinical Pharmacology and Therapeutics - Category: Drugs & Pharmacology Authors: Tags: Clin Pharmacol Ther Source Type: research
Publication date: March 2018 Source:Journal of Solid State Chemistry, Volume 259 Author(s): Yan-Ming Zhao, Gui-Mei Tang, Yong-Tao Wang, Yue-Zhi Cui, Seik Weng Ng Three new chiral metal coordination complexes, namely, [Cu(FZ)2(CH3COO)2(H2O)]·2H2O (1), [Cu(FZ)2(NO3)2] (2), and [Cu2(FZ)2 (H2O)8](SO4)2·4H2O (3) [FZ = (2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoro-4-pyrimidiny)-1-(1H-1,2,4-triazol-1-yl)-2-butanol) (Voriconazole)] have been obtained by the reaction of Cu(II) salts and the free ligand FZ at room temperature. Complexes 1–3 were structurally characterized by X-ray single-crystal diffraction, IR, UV...
Source: Journal of Solid State Chemistry - Category: Chemistry Source Type: research
Publication date: February 2018 Source:Microbial Pathogenesis, Volume 115 Author(s): MubarakAli Davoodbasha, Baldev Edachery, Thajuddin Nooruddin, Sang-Yul Lee, Jung-Wan Kim Fatty acid methyl esters (FAME) derived from lipids of microalgae is known to have wide bio-functional materials including antimicrobials. FAME is an ideal super-curator and superior anti-pathogenic. The present study evaluated the efficiency of FAME extracted from microalgae Scenedesmus intermedius as an antimicrobial agent against Gram positive (Staphylococcus aureus, Streptococcus mutans, and Bacillus cereus) Gram negative (Escherichia coli and Pse...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
Publication date: 5 April 2018 Source:Journal of Molecular Structure, Volume 1157 Author(s): Ayman K. El-Sawaf, Farag El-Essawy, Amal A. Nassar, El-Sayed A. El-Samanody The coordination characteristic of new N4-morpholinyl isatin-3-thiosemicarbazone (HL) towards Co(II), Ni(II), Cu(II), Zn(II) and Pd(II) has been studies. The structures of the complexes were described by elemental analyses, molar conductivity, magnetic, thermal and spectral (IR, UV–Vis, 1H and 13C NMR and ESR) studies. On the basis of analytical and spectral studies the ligand behaves as monobasic tridentate ONS donor forming two five membered rings ...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
In this study, copper sulfate was successfully embedded in filter paper through soaking and copper oxide was successfully embedded in filter paper via in situ technique using the copper sulfate-embedded paper as the starting material. Using color analysis, the filter paper soaked with copper sulfate solution was observed to change color from white to blue, indicating the presence of embedded copper sulfate salts. Furthermore, upon soaking this filter paper with sodium hydroxide solution, the color changed from blue to brown, indicating the presence of copper oxide. X-ray diffraction (XRD) spectroscopy confirms the observed...
Source: Materials Chemistry and Physics - Category: Materials Science Source Type: research
Abstract Carbohydrate esters are biodegradable, and the degraded adducts are naturally occurring carbohydrates and fatty acids which are environmentally friendly and non-toxic to human. A simple one-step regioselective acylation of mono-carbohydrates has been developed that leads to the synthesis of a wide range of carbohydrate esters. Screening of these acylated carbohydrates revealed that several compounds were active against a panel of bacteria and fungi, including Staphylococcus aureus, methicillin-resistant S. aureus (MRSA), Candida albicans, Cryptococcus neoformans, Aspergillus flavus and Fusarium graminearu...
Source: Bioorganic and Medicinal Chemistry - Category: Chemistry Authors: Tags: Bioorg Med Chem Source Type: research
Updated Date: Dec 22, 2017 EST
Source: DailyMed Drug Label Updates - Category: Drugs & Pharmacology Source Type: alerts
Updated Date: Dec 21, 2017 EST
Source: DailyMed Drug Label Updates - Category: Drugs & Pharmacology Source Type: alerts
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