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In Vitro and In Vivo Activity of a Novel Antifungal Small Molecule against Candida Infections

Candida is the most common fungal pathogen of humans worldwide and has become a major clinical problem because of the growing number of immunocompromised patients, who are susceptible to infection. Moreover, the number of available antifungals is limited, and antifungal-resistantCandida strains are emerging. New and effective antifungals are therefore urgently needed. Here, we discovered a small molecule with activity againstCandida spp. bothin vitro andin vivo.
Source: The Aspergillus Website - updates - Category: Respiratory Medicine Authors: Source Type: news

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AbstractChronic suppurative otitis media (CSOM) has a substantial worldwide prevalence and is a major cause of hearing impairment. In cases of CSOM unresponsive to local antibiotics, superimposed fungal infection should be suspected. The aim of the present study was to study the spectrum of cases with fungal otitis media. The study was conducted over a period of 12  years (2006–2017). Fifteen cases of CSOM clinically not suspected to be of fungal etiology that underwent surgery with identification of fungal organisms on histopathology were included in the study. Age of the patients ranged from 12 to 75 year...
Source: Head and Neck Pathology - Category: Pathology Source Type: research
Conclusion: Exposure of organic dust is associated with compromised pulmonary functions and there is a need of formulation of safety guidelines.
Source: Indian Journal of Occupational and Environmental Medicine - Category: Occupational Health Authors: Source Type: research
Updated Date: Apr 13, 2018 EST
Source: DailyMed Drug Label Updates - Category: Drugs & Pharmacology Source Type: alerts
Conclusion The molecular beacon assay is a promising tool providing a rapid method for detection and monitoring of invasive fungal disease in immunosuppressed patients.
Source: Medical Journal Armed Forces India - Category: General Medicine Source Type: research
u-Tsodikova As the threat associated with fungal infections continues to rise and the availability of antifungal drugs remains a concern, it becomes obvious that the need to bolster the antifungal armamentarium is urgent. Building from our previous findings of tobramycin (TOB) derivatives with antifungal activity, we further investigate the effects of various linkers on the biological activity of these aminoglycosides. Herein, we analyze how thioether, sulfone, triazole, amide, and ether functionalities affect the antifungal activity of alkylated TOB derivatives against 22 Candida, Cryptococcus, and Aspergillus species...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
Conclusion: Preoperative recipients ’ status and postoperative kidney dysfunction can affect an occurrence of post-transplant IFI. These risk factors would be taken into consideration for designation of proper antifungal therapy.Dig Surg
Source: Digestive Surgery - Category: Surgery Source Type: research
Conclusion The Aspergillus and Candida species are the most common fungal isolates in otomycosis. Voriconazole and Nystatin are the medications of choice for the treatment of otomycosis in our community. The high virulence of fungal pathogens is owed to their high enzymatic activity. Empirical use of antifungals should be discouraged. [...] Thieme Revinter Publicações Ltda Rio de Janeiro, BrazilArticle in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text
Source: International Archives of Otorhinolaryngology - Category: ENT & OMF Authors: Tags: Original Research Source Type: research
Publication date: Available online 10 April 2018 Source:Journal de Mycologie Médicale Author(s): Z. You, X. Ran, Y. Dai, Y. Ran Skin and soft tissue infections (SSTIs) are very common in dermatology and the use of antimicrobial formulations are important in treating these diseases. With the increasing of drug-resistant strains, researchers need to find ways to enhance the effectiveness and/or reduce the drug resistance. Clioquinol was one of antiseptics that can inactivate microbes. It was lack of data of antimicrobial activity; meanwhile it was infrequently used in infection. In order to research the antimicrobial...
Source: Journal of Medical Mycology - Category: Biology Source Type: research
Published Research Shows Ceragenin CSA-131 ’s Potent Efficacy against Candidaauris, a New Serious Global Health ThreatDUBLIN, OHIO – April 5, 2018 – N8 Medical, LLC today announced a peer-reviewed publication in The Journal ofAntimicrobial Chemotherapy with U.S. Centers for Disease Control and Prevention (CDC) co-authors of promisingefficacy data regarding the activity of ceragenin CSA-131 against 100 strains of Candida auris (C. auris) collected fromaround the world.
Source: The Aspergillus Website - updates - Category: Respiratory Medicine Authors: Source Type: news
Hong Wang Bioassay-guided fractionation of the crude extract of fermentation broth of one symbiotic strain Aspergillus sp. D from the coastal plant Edgeworthia chrysantha Lindl. led to isolation of one new meroterpenoid, tricycloalternarene 14b (1), together with four known analogs (2–5), tricycloalternarenes 2b (2), 3a (3), 3b (4), and ACTG-toxin F (5). Their chemical structures were unambiguously established on the basis of NMR, mass spectrometry, and optical rotation data analysis, as well as by comparison with literature data. Biological assays indicated that compound 2 exhibited potent in vitro cytotoxicity ...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
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