Efficacy of ambruticin analogs in a murine model of invasive pulmonary aspergillosis

Ambruticins are a family of polyketides. The antifungal activity of an ambruticin,KOSN-2079, was tested in the mouse model of invasive aspergillosis.KOSN-2079 significantly reduced pulmonary fungal burdens and improved survival over that with the vehicle control. These results support the continued development of ambruticins as antifungal agents.
Source: The Aspergillus Website - updates - Category: Respiratory Medicine Authors: Source Type: news