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Efficacy of ambruticin analogs in a murine model of invasive pulmonary aspergillosis

Ambruticins are a family of polyketides. The antifungal activity of an ambruticin,KOSN-2079, was tested in the mouse model of invasive aspergillosis.KOSN-2079 significantly reduced pulmonary fungal burdens and improved survival over that with the vehicle control. These results support the continued development of ambruticins as antifungal agents.
Source: The Aspergillus Website - updates - Category: Respiratory Medicine Authors: Source Type: news

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In conclusion, multimodal imaging allows to investigate different aspects of disease progression or recovery by providing complementary information on dynamic processes, which are highly useful for assessing the efficacy of (novel) therapeutic compounds in a time- and labor-efficient manner. PMID: 29760132 [PubMed - as supplied by publisher]
Source: Antimicrobial Agents and Chemotherapy - Category: Microbiology Authors: Tags: Antimicrob Agents Chemother Source Type: research
Abstract LaeA is a conserved global regulator of secondary metabolism and development in filamentous fungi. Examination of Aspergillus fumigatus transcriptome data of laeA deletion mutants have been fruitful in identifying genes and molecules contributing to the laeA mutant phenotype. One of the genes significantly down regulated in A. fumigatus ΔlaeA is metR, encoding a bZIP DNA binding protein required for sulfur and methionine metabolism in fungi. LaeA and MetR deletion mutants exhibit several similarities including down regulation of sulfur assimilation and methionine metabolism genes and ability to grow...
Source: Fungal Genetics and Biology - Category: Biology Authors: Tags: Fungal Genet Biol Source Type: research
Transplant Infectious Disease, EarlyView.
Source: Transplant Infectious Disease - Category: Transplant Surgery Authors: Source Type: research
Infection of the skin by Aspergillus speciesmost commonly occurs through direct innoculation of damaged skin, in which case it is called primary cutaneous aspergillosis (PCA). PCA is often a devastating and life-threatening infection that has been described in all age groups. Premature neonates are at particular risk due to a smaller pool of monocytes and neutrophils, impaired T-cell activation and an immature skin barrier as well as considerably decreased cord blood TNF- α and IL-6. Skin maceration, moisture buildup and disruption of barrier integrity are believed to contribute to the pathophysiology of PCA, and occ...
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Clinical Research: Pathophysiology and Therapeutics Source Type: research
Source: Journal of Clinical Microbiology - Category: Microbiology Authors: Tags: Retraction Source Type: research
Infection of the skin by Aspergillus speciesmost commonly occurs through direct innoculation of damaged skin, in which case it is called primary cutaneous aspergillosis (PCA). PCA is often a devastating and life-threatening infection that has been described in all age groups. Premature neonates are at particular risk due to a smaller pool of monocytes and neutrophils, impaired T-cell activation and an immature skin barrier as well as considerably decreased cord blood TNF- α and IL-6. Skin maceration, moisture buildup and disruption of barrier integrity are believed to contribute to the pathophysiology of PCA, and occ...
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Clinical Research: Pathophysiology and Therapeutics Source Type: research
Conclusions Isolation of NTM or Aspergillus species from lung transplant recipients is uncommon. Adequate pre-transplant control and post-transplant management of NTM and Aspergillus infections allows for safe lung transplantation.
Source: Respiratory Investigation - Category: Respiratory Medicine Source Type: research
Abstract Aspergillosis is an airborne fungal disease caused by Aspergillus spp., a group of ubiquitous molds. This disease causes high morbidity and mortality in both humans and animals. The growing importance of this infection over recent decades has created a need for practical and reproducible models of aspergillosis. The use of laboratory animals provides a platform to understand fungal virulence and pathophysiology, assess diagnostic tools, and evaluate new antifungal drugs. In this review, we describe the fungus, various Aspergillus-related diseases in humans and animals and various experimental animal model...
Source: Comparative Medicine - Category: Zoology Authors: Tags: Comp Med Source Type: research
We present a case of primary Aspergillus appendicitis diagnosed by histologic examination in a patient who underwent lung transplantation.
Source: Transplantation Proceedings - Category: Transplant Surgery Authors: Source Type: research
Abstract Triazole antifungal compounds are the first treatment choice for invasive aspergillosis. However, in the last decade Aspergillus fumigatus azole resistance has increased notoriously. The main resistance mechanisms are well-defined and mostly related to point mutations of the azole target, 14-α sterol demethylase (cyp51A), with or without tandem repeat integrations in the cyp51A promoter. Furthermore, different combinations of five Cyp51A mutations (F46Y, M172V, N248T, D255E and E427K) have been reported worldwide in around 10% of the total A. fumigatus isolated. The azole susceptibility profile of t...
Source: Antimicrobial Agents and Chemotherapy - Category: Microbiology Authors: Tags: Antimicrob Agents Chemother Source Type: research
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