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8 Transplants in 10 days for Solid Organ Transplant

The cases consisted of five kidney transplants, one pancreas transplant, and two liver transplants. Patients hail from Monroe County, Buffalo, Utica and Elmira.
Source: University of Rochester Medical Center Press Releases - Category: Universities & Medical Training Authors: Source Type: news

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Authors: Samy KP, Butler JR, Li P, Cooper DKC, Ekser B Abstract Pig-to-human xenotransplantation offers a potential bridge to the growing disparity between patients with end-stage organ failure and graft availability. Early studies attempting to overcome cross-species barriers demonstrated robust humoral immune responses to discordant xenoantigens. Recent advances have led to highly efficient and targeted genomic editing, drastically altering the playing field towards rapid production of less immunogenic porcine tissues and even the discussion of human xenotransplantation trials. However, as these humoral immune ba...
Source: Journal of Immunology Research - Category: Allergy & Immunology Tags: J Immunol Res Source Type: research
CONCLUSION: There appears to be no specific concern related to liver transplant patients undergoing PD. Peritonitis and mortality rates were no different from other solid organ recipients or even from the general PD population. The hepatic graft was never threatened, even during peritonitis. Therefore, these patients should not be denied the option of PD. PMID: 29162680 [PubMed - as supplied by publisher]
Source: Peritoneal Dialysis International - Category: Urology & Nephrology Tags: Perit Dial Int Source Type: research
CONCLUSION: Peritoneal dialysis appears to be an effective replacement therapy for patients with a previous history of solid-organ transplantation. PMID: 29162679 [PubMed - as supplied by publisher]
Source: Peritoneal Dialysis International - Category: Urology & Nephrology Tags: Perit Dial Int Source Type: research
ABSTRACT Solid organ transplantation is a significant development in the treatment of chronic kidney, liver, heart and lung diseases. This therapeutic approach has increased patient survival and improved quality of life. New surgical techniques and immunosuppressive drugs have been developed to achieve better outcomes. However, the variety of neurological complications following solid organ transplantation is broad and carries prognostic significance. Patients may have involvement of the central or peripheral nervous system due to multiple causes that can vary depending on time of onset after the surgical procedure, the tr...
Source: Arquivos de Neuro-Psiquiatria - Category: Neurology Source Type: research
Aims: To study the association between higher versus lower continuous renal replacement therapy (CRRT) intensity and mortality in critically ill patients with combined acute kidney injury and liver dysfunction.Methods: Post-hoc analysis of patients with liver dysfunction (Sequential Organ Failure Assessment liver score ≥2 or diagnosis of liver failure/transplant) included in the Randomized Evaluation of Normal versus Augmented Level renal replacement therapy (RENAL) trial.Results: Of 444 patients, 210 (47.3%) were randomized to higher intensity (effluent flow 40 mL/kg/h) and 234 (52.7%) to lower intensity (effluent flow...
Source: Blood Purification - Category: Hematology Source Type: research
Abstract Background and aims: Calcineurin inhibitors (CNI) frequently induce neurological complications early after orthotopic liver transplantation (OLT). We hypothesize that long‐term CNI therapy after OLT causes dose‐dependent cognitive dysfunction and alteration of brain structure. Methods: Eighty‐five OLT patients (20 with CNI free, 35 with CNI low dose and 30 with standard dose CNI immunosuppression) underwent psychometric testing and cerebral magnetic resonance tomography about 10 years after OLT to assess brain function and structural brain alterations. Thirty‐three healthy subjects adjusted for age, gender...
Source: Liver Transplantation - Category: Transplant Surgery Authors: Tags: Original Article Source Type: research
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Source: American Journal of Transplantation - Category: Transplant Surgery Authors: Tags: Letter to the Editor Source Type: research
This study cohort is a healthy subset of the EpiPath cohort, excluding all participants with acute or chronic diseases. With a mediation analysis we examined whether CMV titers may account for immunosenescence observed in ELA. In this study, we have shown that ELA is associated with higher levels of T cell senescence in healthy participants. Not only did we find a higher number of senescent cells (CD57+), these cells also expressed higher levels of CD57, a cell surface marker for senescence, and were more cytotoxic in ELA compared to controls. Control participants with high CMV titers showed a higher number of senes...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Publication date: Available online 8 November 2017 Source:Journal of Clinical and Experimental Hepatology Author(s): Anil C. Anand As the cirrhosis progresses, development of complication like ascites, hepatic encephalopathy, variceal bleeding, kidney dysfunction, and hepatocellular carcinoma signify increasing risk of short term mortality. Malnutrition and muscle wasting (sarcopenia) is yet other complications that negatively impact survival, quality of life, and response to stressors, such as infection and surgery in patients with cirrhosis. Conventionally, these are not routinely looked for, because nutritional assessm...
Source: Journal of Clinical and Experimental Hepatology - Category: Gastroenterology Source Type: research
Condition:   The Recipients Undergoing Liver Transplantation Intervention:   Sponsor:   Yonsei University Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
More News: Kidney Transplant | Kidney Transplantation | Liver | Liver Transplant | Pancreas | Transplant Surgery | Transplants | Urology & Nephrology