Swine flu may double risk for type 1 diabetes
Norwegians infected with the H1N1 influenza virus were twice as likely to develop type 1 diabetes, according to findings presented at the European Association for the Study of Diabetes Annual Meeting.Healio
In this study, aqueous suspensions of various active ingredients (A.I.s) were utilized to generate Engineered Water Nanostructures (EWNS) nano-sanitizers, containing the A.I. utilized to produced them (termed iEWNS). These iEWNS had nanoscale size, were loaded with ROS and contained the A.I. utilized to produce them. They were challenged with Influenza H1N1/PR/8 and Acinetobacter baumannii on surfaces and in air. The results indicate that a nanogram dose of A.I. is effective in producing significant inactivation in Influenza H1N1/PR/8 and Acinetobacter baumannii.
Painful diabetic neuropathy (PDN) is an intractable complication of diabetes that affects 25% of patients. PDN is characterized by neuropathic pain and small-fiber degeneration, accompanied by dorsal root ganglion (DRG) nociceptor hyperexcitability and loss of their axons within the skin. The molecular mechanisms underlying DRG nociceptor hyperexcitability and small-fiber degeneration in PDN are unknown. To delineate the molecular mechanisms behind nociceptor hyperexcitability and small-fiber degeneration, it becomes important to uniquely identify changes in the nociceptor population from within the heterogeneous populatio...
Pain is a tremendous health care burden associated with prediabetes and diabetes. However, not everyone with prediabetes or diabetes develops pain and the factors that increase susceptibility to painful neuropathy remain elusive. The epidermis is innervated by both peptidergic and nonpeptidergic axons and our studies in mice reveal that mechanical allodynia induced by consuming a high fat diet increases peptidergic epidermal axons. We hypothesize that patients with prediabetes and painful neuropathy have an abnormal proportion of epidermal peptidergic axons.
The current study assessed associations of clinical characteristics and all-cause mortality among a cohort of Veterans initiating pain services. Analyses were also stratified by age to examine potential variations. Demographic (male, age), medical comorbidities (diabetes, myocardial infarction, chronic pulmonary conditions, cancer, renal disease, liver disease), pain characteristics (pain intensity, opioid analgesic prescription), and mental health characteristics (depression, opioid use disorder, opioid poisoning/suicide attempts) were extracted from Veterans Health Administration records.
NYX-2925, a novel small-molecule modulator of the N-methyl-D-aspartate receptor (NMDAR), was evaluated in a randomized, double-blind, placebo-controlled study, in which 302 subjects with painful DPN received daily oral doses of placebo or NYX-2925 at 10mg, 50mg, or 200mg for four weeks (NCT03219320). This first-in-patient study was conducted across 35 U.S.-based sites and subjects were randomized in a 1:1:1:1 ratio. Average pain intensity was collected using the 11-point Numerical Rating Scale and subjects were assessed for randomization eligibility using a proprietary algorithm employed to improve assay sensitivity.
According to the Centers for Disease Control and Prevention, approximately 50 percent of the 30 million Americans with diabetes suffer from diabetic neuropathy, which results in numbness and tingling in one's limbs. As the disease progresses, 50 percent of the diabetic neuropathy patients develop neuropathic pain as a result of damage to the peripheral nerves which can produce debilitating limb pain. Despite an improved understanding of the molecular mechanisms of nociception, most clinical trials still use self-reported measures of pain as their primary efficacy endpoint.
Publication date: Available online 20 March 2019Source: Food Research InternationalAuthor(s): Erika V. Mejía, Karla A. Batista, Juan Jose A. Fernández, Kátia F. FernandesAbstractThe present study was undertaken to examine the antidiabetic potential of naturally occurring peptides and hydrolysate fractions from easy-to-cook (ETC) and hard-to-cook (HTC) beans. All fractions were tested regarding their in vitro inhibitory activities against α-amylase and α-glucosidase as well as in vivo anti-hyperglycemic and hypoglycemic effects. Results evidenced that the peptide fractions with the lowest molecular weight (
Publication date: April 2019Source: Current Opinion in Virology, Volume 35Author(s): Rosemary Morgan, Sabra L KleinMales/men and females/women differ in the outcome of influenza A virus (IAV) infections, vaccination, and antiviral treatments. Both sex (i.e. biological factors) and gender (i.e. sociocultural factors) can impact exposure and severity of IAV infections as well as responses and outcomes of treatments for IAV. Greater consideration of the combined effects of sex and gender in epidemiological, clinical, and animal studies of influenza pathogenesis is needed.Graphical abstract
Publication date: Available online 20 March 2019Source: Preventive Veterinary MedicineAuthor(s): Bin Cui, Zong Ping Liu, Jun Ke, Yi TianAbstractThe implementation of biosecurity measures among farmers is the first line of defense against highly pathogenic avian influenza (HPAI) on poultry farms. Yet much less is known about the association between HPAI outbreak information sources, farmers’ risk perception and their adoption of biosecurity behaviors (BBs). To bridge this gap, a survey (n = 426) was conducted to measure the relationship between these factors among poultry farmers in the Chinese provinces...
Retraction notice to "Activity of ultra-low doses of antibodies to gamma-interferon against lethal influenza A(H1N1)2009 virus infection in mice" [Antiviral Research 93 (2012) 219-224]. Antiviral Res. 2019 Apr;164:177 Authors: Tarasov SA, Zarubaev VV, Gorbunov EA, Sergeeva SA, Epstein OI PMID: 30885299 [PubMed - in process]