Fibroblasts That Resist Cigarette Smoke-induced Senescence Acquire Pro-fibrotic Phenotypes.

Conclusions: Extended exposure to CSE might induce two different fibroblast phenotypes, a senescent and a pro-fibrotic phenotype. The fibroblasts that resist CSE-induced cellular senescence may contribute to the pathogenesis of IPF and could contribute to fibrotic lesions in COPD acting through a TGF-β1 mediated pathway. In contrast, the senescent cells may contribute to the pathogenesis of emphysema.
PMID: 25015975 [PubMed - as supplied by publisher]

Source: Am J Physiol Lung Ce... - July 11, 2014 Category: Respiratory Medicine Authors: Kanaji N, Basma H, Nelson AJ, Farid M, Sato T, Nakanishi M, Wang X, Michalski J, Li Y, Gunji Y, Feghali-Bostwick CA, Liu X, Rennard SI Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research