Genetic and Epigenetic Insights into Uveal Melanoma.

Genetic and Epigenetic Insights into Uveal Melanoma.
Clin Genet. 2017 Sep 13;:
Authors: Sharma A, Stei MM, Fröhlich H, Holz FG, Loeffler KU, Herwig-Carl MC
Abstract
Uveal melanoma (UM) is the most frequent primary intraocular tumor in Caucasian adults and is potentially fatal if metastases develop. While several prognostic genetic changes have been identified in UM, epigenetic influences are now getting closer attention. Recent technological advances have allowed to examine the human genome to a greater extent and have improved our understanding of several diseases including malignant tumors. In this context, there has been tremendous progress in the field of UM pathogenesis. Herein, we review the literature with emphasis on genetic alterations, epigenetic modifications and signaling pathways as well as possible biomarkers in UM. In addition, different research models for UM are discussed. New insights and major challenges are outlined in order to outline the current status for this potentially devastating disease.
PMID: 28902406 [PubMed - as supplied by publisher]

Source: Clinical Genetics - September 13, 2017 Category: Genetics & Stem Cells Authors: Sharma A, Stei MM, Fröhlich H, Holz FG, Loeffler KU, Herwig-Carl MC Tags: Clin Genet Source Type: research