In vitro metabolism of the synthetic cannabinoids CUMYL-PINACA, 5F-CUMYL-PINACA, CUMYL-4CN-BINACA, 5F-CUMYL-P7AICA and CUMYL-4CN-B7AICA - Staeheli SN, Poetzsch M, Veloso VP, Bovens M, Bissig C, Steuer AE, Kraemer T.

Synthetic cannabinoid consumption trends underlie fast changes and provide several challenges to clinical and forensic toxicologists. Due to extensive metabolism parent compounds are hardly detectable in urine. Therefore, knowledge on the metabolism of syn...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

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ConclusionsThese data show that ethanol shifts animals toward behaving habitually. This may illuminate why alcohol-intoxicated individuals display impaired judgment about the relative merits of drinking, and potentially serve as a mechanism by which intoxicated subjects resume previously devalued behaviors, such as comorbid drug use. These findings also show that high variable interval response rates facilitate a shift from goal-directed to habitual behavior.
Source: Psychopharmacology - Category: Psychiatry Source Type: research
Three experiments were conducted. Experiment 1 evaluated the effects of 24-h exposure of extender (INRA96, IMV Technologies, L ’Aigle, France) to rubber at four different temperatures (4°, 22°, 38°, or 45°C) on semen quality. Artificial vagina (AV) rubber from 3 sources (Reproduction Resources [RR], Animal Reproduction Systems [ARS], and NASCO) was subjected to several cleaning methods (DI water only [R], washed with detergent and rinsed with DI water [D], or soaked in alcohol and rinsed with DI water [A]).
Source: Journal of Equine Veterinary Science - Category: Veterinary Research Authors: Source Type: research
Self-written waveguide (SWW) trajectories fabricated inside a dry photopolymer bulk material, acrylamide/polyvinyl alcohol (AA/PVA), are studied. Their production using both Gaussian and Laguerre – Gauss exposing (writing) light beams, output from optical fibers, is explored. The formation of ...
Source: Applied Optics - Category: Physics Authors: Source Type: research
This study aimed to elucidate the anti-inflammatory, anti-oxidant and antifibrotic effects of gold nanoparticles (GNPs) in rats subjected to liver injury with ethanol and Methamphetamine (METH). The liver injury was induced by gavage administrations of 30% alcoholic solution (7 g/kg) once a day during 28 days, followed by METH (10 mg/kg) on the 20th and 28th days of treatment. GNPs treatment (724.96 µg/kg) during the ethanol and METH exposure was associated with reduced steatosis, hepatic cord degeneration, fibrosis and necrosis. Furthermore, there was a reduction in biochemical markers of liver damage and ...
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research
We report a case of a 30 year old male Caucasian patient with accidental severe hypothermia who was transferred to the emergency department of our hospital after prolonged exposure in the urban city's night environment cold as a result of alcohol and drugs abuse. The patient was found unconscious in the first early hours from onlookers. The time that the patient remained unconscious is unknown. During the transfer to the hospital because of cardiac arrest cardiopulmonary resuscitation began. In the emergency department an extracorporeal life support system (ECLS) was implanted under cardiopulmonary resuscitation in order t...
Source: Respiratory Medicine Case Reports - Category: Respiratory Medicine Source Type: research
Publication date: 2018 Source:Respiratory Medicine Case Reports, Volume 25 Author(s): Yonas Raru, Fuad Zeid Valproic acid (VPA) is widely used for the treatment of epilepsy, migraine, and a variety of psychiatric symptoms, including bipolar disorder, borderline personality disorder, and alcohol withdrawal. Valproate is associated with severe idiosyncratic adverse effects, the most notable being valproate-induced hyperammonemic encephalopathy (VHE). Topiramate is also a broad-spectrum anticonvulsant that is also extensively used for migraine prophylaxis, as a mood stabilizer, and for alcohol dependency. There is increased ...
Source: Respiratory Medicine Case Reports - Category: Respiratory Medicine Source Type: research
We present a case of diffuse alveolar hemorrhage (DAH) resulting from marijuana inhalation, a finding rarely described in the literature. A 21-year-old male presented with several episodes of hemoptysis after drinking alcohol and smoking marijuana. He reported smoking 5–8 joints per day of marijuana (he denied use of bongs or other inhalant aids). His respiratory exam revealed bilateral fine rales. Laboratory evaluation included leukocytosis with left shift, normal platelets, coagulation profile, and a urine toxicology screen positive for tetrahydocanabinoid (THC). Chest CT revealed bilateral diffuse alveolar infiltr...
Source: Respiratory Medicine Case Reports - Category: Respiratory Medicine Source Type: research
Researchers at theUCLA Fielding School of Public Health have received a five-year,  $9.5 million grant from the National Institute on Drug Abuse to continue research on possible connections between substance abuse and HIV infection. The new phase of the study began this month; it continues work that started in 2013 with a $7 million grant from NIDA. Approximately two-thirds of new HIV infections in the U.S. occur among Latino and African-American men who have sex with men; and studies show that drug abuse is linked with poor adherence to HIV medication and prevention therapies.The grant will enable researchers to...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
This is not a pleasant article to write. But then how could it be pleasant when I am writing about suicide. Yet, it’s important for all of us to attempt to understand the suicidal mind. My interest in this topic began when I was in my mid-twenties, with the attempted suicide of my mother. My mother’s act of aggression did not come out of the blue. She was depressed; she was drinking; she demanded that life bend to her demands. When it seemed that life was going to do as it damn well pleased, she, in a fit of anger and despair, decided to take matters into her own hands. While she lived for many more years after...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Depression Inspiration & Hope Personal Suicide anthony bourdain Feeling Of Hopelessness kate spade Source Type: blogs
PREDIMED (again), malpractice concerns in CAD testing, alcohol, stroke care in the elderly, and genetic testing are the topics discussed by Dr John Mandrola in this week ’ s podcasttheheart.org on Medscape
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Cardiology Commentary Source Type: news
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