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Distal Bicep Tendon Rip Tied to Transthyretin Amyloidosis

Findings in patients with heart failure with preserved ejection fraction
Source: Pulmonary Medicine News - Doctors Lounge - Category: Respiratory Medicine Tags: Cardiology, Internal Medicine, Orthopedics, Pathology, Pulmonology, Journal, Source Type: news

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As this 40-year longitudinal study illustrates, when measuring the correlation between specific risk factors on specific forms of mortality, their influence can appear to decline in later life. That is to say that mortality rates keep rising with advancing age, but they are less obviously influenced by any one cause for a given cohort of individuals. This effect occurs because the fatal consequences of a particular form of age-related dysfunction will tend to occur earlier in old age for individuals with the highest risk. With each passing year, a given age group is ever more made up of resilient survivors, people who - fo...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
Cardiac amyloidosis – most commonly resulting from deposition of misfolded light chain (AL) or transthyretin (ATTR) protein - is an underappreciated cause of heart failure.[1, 2] Commonly thought to be a rare disease, undiagnosed cardiac amyloidosis has been identified in numerous populations including 10-20% of elde rly patients with heart failure and preserved ejection fraction (HFpEF),[3] severe aortic stenosis,[4] and Afro-Caribbean patients with decompensated heart failure.[5] Despite this recent evidence, many clinicians indicate that they have never seen a case of cardiac amyloidosis, suggesting that the diagn...
Source: Journal of Cardiac Failure - Category: Cardiology Authors: Tags: Editorial Source Type: research
Cardiac transthyretin amyloidosis (aTTR-CA) is an increasingly recognized cause of heart failure and carries an unfavorable prognosis. There has been no systematic investigation of how long prodromal symptoms are present before the diagnosis of aTTR-CA. We sought to document the type, frequency and distribution of early clinical manifestations in aTTR-CA in order to identify the earliest possible time window for diagnosis.
Source: Journal of Cardiac Failure - Category: Cardiology Authors: Tags: Research Letter Source Type: research
Abstract Immunoglobulin light‐chain amyloidosis (AL) affects multiple organs, most prominently the kidney and the heart. Renal and cardiac impairment are both associated with poor prognosis and most patients die as a consequence of renal or cardiac failure. Monoclonal antibodies such as daratumumab (human IgG1 anti‐CD38) and elotuzumab (anti‐SLAMF7) have shown promising efficacy for the treatment of relapsed and refractory multiple myeloma. In this case report we show 2 patients with severe AL, one with severe heart failure and one with heart and renal failure, undergoing treatment with daratumumab. Both patients sho...
Source: European Journal of Haematology - Category: Hematology Authors: Tags: CASE REPORT Source Type: research
Conclusions TTR-FA may manifest in the coronary arteries with ectasia. Ablation for AF in TTR-FA may be unsuccessful. Tafamidis has been unsuccessful for cardiac or nerve involvement after the first seven months.
Source: Heart and Lung: The Journal of Acute and Critical Care - Category: Respiratory Medicine Source Type: research
We present a case of amyloidosis AL with isolated myocardial involvement. Because of a refractory heart failure picture, patient underwent orthotopic heart transplant (OHT). The replaced heart showed an important midwall infiltration. Ten months after he underwent autologous stem-cell transplantation (ASCT) with a favorable outcome. The case demonstrates that OHT followed by ASCT in highly selected patients with light chain amyloidosis is a life-saving procedure.
Source: Cor et Vasa - Category: Cardiology Source Type: research
Source: European Journal of Heart Failure - Category: Cardiology Authors: Tags: Editorial Comment Source Type: research
In conclusion, we have developed an effective PILs strategy to deliver the AUF1 plasmid to a specific target, and this system may be useful for the development of new anti-aging drugs. Considering the Evidence for Vascular Amyloidosis as a Cause of Aging https://www.fightaging.org/archives/2017/11/considering-the-evidence-for-vascular-amyloidosis-as-a-cause-of-aging/ The balance of evidence for the aging of the cardiovascular system suggests the following view. It starts off in the blood vessels, with the accumulation of senescent cells and cross-links. Cross-links directly stiffen these tissues, while ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
AbstractPurpose of ReviewVentricular arrhythmias (VAs) are a significant cause of morbidity and mortality in patients with cardiomyopathy (CM). This review focuses on ventricular tachycardia (VT) management in uncommon causes of heart disease, such as inflammatory and infiltrative CMs.Recent FindingsIntegration of advanced cardiac imaging modalities, such as cardiac magnetic resonance imaging (MRI) and positron emission tomography (PET), into diagnostic evaluation of patients with CM may unmask abnormal myocardial substrate in almost half of patients presenting with VAs. Stepwise approach to management of VAs in cardiac sa...
Source: Current Cardiovascular Risk Reports - Category: Cardiology Source Type: research
Abstract Cardiac amyloidosis (CA) has been believed to be a rare disease for a long time, but recent sophisticated diagnostic modalities demonstrate that a considerable number of CA patients are hidden among those diagnosed with heart failure. Prognosis of CA was poor, but recent developments in therapeutic interventions have improved survival in these patients. Therefore, early detection and precise diagnosis is clinically important. In this review article, we overview recent progress in diagnosis and treatment for CA. PMID: 29113705 [PubMed - as supplied by publisher]
Source: Journal of Cardiology - Category: Cardiology Authors: Tags: J Cardiol Source Type: research
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