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Distal Bicep Tendon Rip Tied to Transthyretin Amyloidosis

Findings in patients with heart failure with preserved ejection fraction
Source: Pulmonary Medicine News - Doctors Lounge - Category: Respiratory Medicine Tags: Cardiology, Internal Medicine, Orthopedics, Pathology, Pulmonology, Journal, Source Type: news

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This cross-sectional study compares the frequency of rupture of the distal biceps tendon in patients with wild-type transthyretin amyloidosis cardiomyopathy vs those with other causes of heart failure.
Source: JAMA - Category: General Medicine Source Type: research
AbstractCardiac amyloidosis is a form of restrictive cardiomyopathy resulting in heart failure and potential risk on arrhythmia, due to amyloid infiltration of the nerve conduction system and the myocardial tissue. The prognosis in this progressive disease is poor, probably due the development of cardiac arrhythmias. Early detection of cardiac sympathetic innervation disturbances has become of major clinical interest, because its occurrence and severity limits the choice of treatment. The use of iodine-123 labelled metaiodobenzylguanidine ([I-123]MIBG), a chemical modified analogue of norepinephrine, is well established in...
Source: Journal of Nuclear Cardiology - Category: Nuclear Medicine Source Type: research
Abstract AimThe aim of this study was to evaluate the diagnostic utility of high‐sensitivity cardiac troponin T (hs‐cTnT) levels in discriminating cardiac amyloidosis from patients with cardiac hypertrophy caused by aetiologies other than cardiac amyloidosis. Methods and resultsSerum hs‐cTnT levels were measured in 96 patients with cardiac amyloidosis (light chain: 23, wild‐type transthyretin amyloidosis: 40, and mutated transthyretin amyloidosis: 33), and 91 patients with other causes of cardiac hypertrophy who were confirmed to have no cardiac amyloidosis by endomyocardial biopsy (control group). The diagnostic u...
Source: ESC Heart Failure - Category: Cardiology Authors: Tags: Original Research Article Source Type: research
Source: European Journal of Heart Failure - Category: Cardiology Authors: Tags: Editorial Comment Source Type: research
Publication date: Available online 30 August 2017 Source:Journal of Cardiology Cases Author(s): Genzou Takemura, Hiromitsu Kanamori, Hideshi Okada, Akiko Tsujimoto, Nagisa Miyazaki, Shusaku Miyata, Hideaki Ohta, Yoshiaki Kawase, Makoto Ono, Mamoru Mochizuki, Shigeki Kobayashi, Kenji Onoue, Tomoya Nakano, Yasuhiro Sakaguchi, Hitoshi Matsuo, Masafumi Yano, Yoshihiko Saito During electron microscopic examination of 156 consecutive human endomyocardial biopsy specimens, we found marked mitochondrial deformity within a single cardiomyocyte in each of 4 specimens. The deformed mitochondria were unevenly distributed, but the def...
Source: Journal of Cardiology Cases - Category: Cardiology Source Type: research
This study aimed to characterize invasive haemodynamics during exercise in subjects with cardiac amyloidosis (CA). Methods and resultsThe study population numbered 44 subjects. Group A (CA‐positive, n = 24) comprised wild‐type transthyretin patients (n = 10), familial transthyretin amyloidosis mutation carriers (ATTRm) with cardiac involvement (n = 5), and light‐chain amyloidosis patients with cardiac involvement (n = 9). Group B (CA‐negative, n = 20) comprised four healthy ATTRm subjects without cardiac involvement documented by 11...
Source: European Journal of Heart Failure - Category: Cardiology Authors: Tags: Original Article Source Type: research
CONCLUSION: The adopted post-processing algorithm determines long T1 values with high accuracy and short T1 values while maintaining a high precision. Based on reduction of waiting time, and independence of heart rate, it shortens breath hold duration and allows fast T1-mapping, which is frequently a prerequisite in patients with cardiac diseases. PMID: 28801204 [PubMed - as supplied by publisher]
Source: Zeitschrift fur Medizinische Physik - Category: Radiology Authors: Tags: Z Med Phys Source Type: research
Introduction: Cardiac amyloidosis is an infiltrative process most commonly caused by abnormal deposition of precursor proteins from monoclonal light chain (AL) or transthyretin (hereditary ATTRmt or wild-type ATTRwt). ATTRwt is increasingly recognized as an important cause of heart failure, especially in those over age 60, but diagnosis is challenging and historically often required cardiac biopsy. Bone scintigraphy using 99mtechnetium-labeled pyrophosphate (99mTc-PYP) has been reported to have high specificity at 99% for ATTR in studies to date.
Source: Journal of Cardiac Failure - Category: Cardiology Authors: Source Type: research
Introduction: The true prevalence of heart failure (HF) due to wild type transthyretin amyloidosis (ATTRwt) is likely drastically underestimated, and there is little data to guide the management of advanced HF due to ATTRwt. Futhermore, the natural history of extracardiac ATTRwt has not been well elucidated. Methods: We conducted an observational retrospective cohort study of consecutive unselected patients undergoing cardiac transplant for ATTRwt at a single institution. Comprehensive clinical data, including baseline hemodynamic and echocardiographic characteristics; rejections; hospitalization; and causes of death were obtained.
Source: Journal of Cardiac Failure - Category: Cardiology Authors: Source Type: research
Introduction: Transthyretin cardiomyopathy (ATTR-CM) is a rare, progressively fatal disease caused by accumulation of misfolded TTR amyloid fibrils in the heart, leading to restrictive cardiomyopathy and heart failure. The structural instability of the TTR tetramer can occur due to genetic mutations of the gene encoding TTR protein or can be associated with aging (wild-type). The Transthyretin Amyloidosis Outcomes Survey is an ongoing, longitudinal, international registry of individuals diagnosed with or at risk (carrying a mutation) for TTR amyloidosis.
Source: Journal of Cardiac Failure - Category: Cardiology Authors: Source Type: research
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