18F-AV-1451 binds to motor-related subcortical gray and white matter in corticobasal syndrome

Conclusions:
18F-AV-1451 asymmetrically binds to motor-related subcortical gray and white matter structures in patients with CBS. This pattern corresponds to tau pathology distribution in postmortem studies, and motor deficit in patients with CBS may be associated with tau accumulation predominantly in the subcortical white matter underlying the motor cortex, leading to disruptions in motor-related networks.

Source: Neurology - September 11, 2017 Category: Neurology Authors: Cho, H., Baek, M. S., Choi, J. Y., Lee, S. H., Kim, J. S., Ryu, Y. H., Lee, M. S., Lyoo, C. H. Tags: PET ARTICLE Source Type: research