Granulomatosis with Polyangiitis Presenting with Pyoderma Gangrenosum –Like Ulceration and Negative Cytoplasmic Antineutrophilic Cytoplasmic Antibodies in a Child
We present the case of a 12‐year‐old boy with pyoderma gangrenosum–like ulcerations on his lower extremity as the initial manifestation of GPA despite negative cytoplasmic antineutrophilic cytoplasmic antibodies (c‐ANCAs). Although GPA is strongly associated with c‐ANCA, c‐ANCA may be negative on presentation. Thus clinical and pathologic clues must be relied upon when serologic confirmation is negative.
Source: Pediatric Dermatology - Category: Dermatology Authors: Ashley Kass, Jake D. Fagan, Paul Long Tags: Case Report Source Type: research
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