P 41 Mitochondrial pathology in PM-Mito and sIBM

Polymyositis with mitochondrial pathology (PM-Mito) (Temiz et al., 2009) comprises a subgroup of inflammatory myopathies whose pathophysiological and clinical significance is not clear.Besides the lymphocytic infiltrates the PM-Mito (Siepmann et al., 2013) shares the histological finding of mitochondrial abnormalities with the sporadic inclusion body myositis (sIBM), in particular the occurrence of cytochrome-C-oxydase (COX)-deficient muscle fibres and subsarkolemmal accumulation of mitochondria (Rygiel et al., 2016; Lindgren et al., 2015).

Source: Clinical Neurophysiology - September 8, 2017 Category: Neuroscience Authors: I. Schneider, P. Joshi, G. Stoltenburg-Didinger, T. Kraya, S. Zierz Tags: Poster Source Type: research