Expression of ADAMTS13 in Normal and Abnormal Placentae and Its Potential Role in Angiogenesis and Placenta Development.

CONCLUSIONS: Our results demonstrate for the first time the expression of ADAMTS13 mRNA and protein in normal and abnormal placental tissues and its role in promoting angiogenesis and trophoblastic cell development. The findings support the potential role of the ADAMTS13-von Willebrand factor pathway in normal pregnancy and pathogenesis of preeclampsia.
PMID: 28751574 [PubMed - indexed for MEDLINE]

Source: Arteriosclerosis, Thrombosis and Vascular Biology - September 1, 2017 Category: Cardiology Authors: Xiao J, Feng Y, Li X, Li W, Fan L, Liu J, Zeng X, Chen K, Chen X, Zhou X, Zheng XL, Chen S Tags: Arterioscler Thromb Vasc Biol Source Type: research