The phenylephrine concentration ‐response relationship for blood pressure after nasal delivery in children

ConclusionAbsorption of phenylephrine through the nasal mucosa was rapid and similar to the ophthalmic formulation. Bioavailability was also similar to the ophthalmic formulation. The maximum effect (EMAX) in children was half that in adults (EMAX 50 mm Hg).

http://onlinelibrary.wiley.com/resolve/doi?DOI=10.1111%2Fpan.13221

Source: Pediatric Anesthesia - September 1, 2017 Category: Anesthesiology Authors: Brian J. Anderson, Lisa K. Christensen, Valerie E. Armstead, David P. Bilyeu, Kenneth E. Johnson, Robert H. Friesen Tags: RESEARCH REPORT Source Type: research