treatment resistant bipolar/schizophrenia?

At my job I've inherited some of the more complex cases after someone in my hospital system left. It is a population of veterans who get intensive case management and a number of them are diagnosed with treatment resistant schizophrenia/bipolar disorder. Classically, I was taught that if someone fails two antipsychotic trials, it is not unreasonable to consider clozapine and there is not much evidence for multiple antipsychotics. However, a number of my new vets are on 2 antipsychotics and... treatment resistant bipolar/schizophrenia?
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Source Type: forums