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Correlation between Intravoxel Incoherent Motion Magnetic Resonance Imaging Derived Metrics and Serum Soluble CD40 Ligand Level in an Embolic Canine Stroke Model.

Correlation between Intravoxel Incoherent Motion Magnetic Resonance Imaging Derived Metrics and Serum Soluble CD40 Ligand Level in an Embolic Canine Stroke Model. Korean J Radiol. 2017 Sep-Oct;18(5):835-843 Authors: Xu XQ, Wu CJ, Lu SS, Gao QQ, Zu QQ, Liu XL, Shi HB, Liu S Abstract OBJECTIVE: To determine the relationship between intravoxel incoherent motion (IVIM) imaging derived quantitative metrics and serum soluble CD40 ligand (sCD40L) level in an embolic canine stroke model. MATERIALS AND METHODS: A middle cerebral artery occlusion model was established in 24 beagle dogs. Experimental dogs were divided into low- and high-sCD40L group according to serum sCD40L level at 4.5 hours after establishing the model. IVIM imaging was scanned at 4.5 hours after model establishment using 10 b values ranging from 0 to 900 s/mm(2). Quantitative metrics diffusion coefficient (D), pseudodiffusion coefficient (D(*)), and perfusion fraction (f) of ischemic lesions were calculated. Quantitative metrics of ischemic lesions were normalized by contralateral hemisphere using the following formula: normalized D = Dstroke / Dcontralateral. Differences in IVIM metrics between the low- and high-sCD40L groups were compared using t test. Pearson's correlation analyses were performed to determine the relationship between IVIM metrics and serum sCD40L level. RESULTS: The high-sCD40L group showed significantly lower f and normalized f values than the low-sCD40L group (f,...
Source: Korean J Radiol - Category: Radiology Authors: Tags: Korean J Radiol Source Type: research

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Source: Platelets - Category: Hematology Tags: Platelets Source Type: research
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Source: Developmental Medicine and Child Neurology - Category: Child Development Authors: Tags: Original Article Source Type: research
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Source: American Journal of Neuroradiology - Category: Radiology Authors: Tags: INTERVENTIONAL Source Type: research
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Source: Thrombosis and Haemostasis - Category: Hematology Authors: Tags: Thromb Haemost Source Type: research
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Source: International Journal of Clinical Practice - Category: Internal Medicine Authors: Tags: SHORT REPORT Source Type: research
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Source: International Journal of Cardiology - Category: Cardiology Authors: Tags: Editorial Source Type: research
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Source: European Journal of Neurology - Category: Neurology Authors: Tags: Original Article Source Type: research
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Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
CONCLUSION: In this review, we summarized a number of expression systems based on recombinant DNA technology and protein-engineering approaches, which have developed for the production of engineered recombinant SAK molecules with higher fibrinolytic activities and lower antigenicity. PMID: 29424308 [PubMed - as supplied by publisher]
Source: Current Pharmaceutical Biotechnology - Category: Biotechnology Authors: Tags: Curr Pharm Biotechnol Source Type: research
AbstractBackgroundMagnetic resonance imaging (MRI) is the diagnostic cornerstone for precisely identifying acute ischaemic strokes and locating vascular occlusions, especially since mechanical thrombectomy has become a reference treatment. We observed that a post-contrast three-dimensional turbo-spin-echo T1-weighted sequence showed striking post-contrast vascular hyperintensities (PCVH) in ischaemic territories. We aimed to evaluate the prevalence and the meaning of this finding.MethodsThis retrospective single centre study included 130 consecutive patients admitted for acute ischaemic stroke with a 3-T MRI performed in t...
Source: European Radiology - Category: Radiology Source Type: research
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