Phase 2, Randomized, Double-Blind, Placebo Controlled Study of Inecaclcitol Combined with Decitabine versus Decitabine: A New Treatment Strategy for Elderly AML Patients Unfit for Intensive Chemotherapy

Leukemogenesis is a multistep process with mutations conferring an advantage in proliferation and others leading to a blockade of maturation. Available treatments are targeting proliferation. Vitamine D is a differentiating agent acting through the Vitamin-D Receptor (VDR). AML patients ’ prognosis is correlated to VDR expression. Promoter of VDR is highly methylatded in AML cells and limits transcriptional responsiveness of VDR. This could explain the disappointing results from previous clinical trials of vitamin D.
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Authors: Source Type: research