NHS no longer uses post-it notes for heart transplants
The pioneering system is 300 times faster, NHS Blood and Transplant experts claim, and has removed around 40 lengthy steps from the organ matching process.
The ever expanding epidemic of end-stage heart failure represents one of the greatest challenges of modern cardiovascular medicine. With medical treatments hampered by significant limitations, physicians caring for patients with advanced heart disease have turned to cardiac transplantation and durable mechanical circulatory assist devices as definitive therapies. These advanced therapeutic modalities are not widely available outside the United States and Europe, but nevertheless offer enormous potential for patients in the Arab Gulf suffering from end-stage heart failure. This review will discuss the management of end-stag...
Adult congenital heart disease (ACHD) prevalence is increasing worldwide with advanced heart failure (HF) as a leading cause of mortality. Limited data are available on durable mechanical circulatory support (MCS) in ACHD patients.
Conclusions The prevalence of depression and severe distress is common among heart transplant recipients. Patients with many comorbidities are at higher risk of psychological indisposition.
This study cohort is a healthy subset of the EpiPath cohort, excluding all participants with acute or chronic diseases. With a mediation analysis we examined whether CMV titers may account for immunosenescence observed in ELA. In this study, we have shown that ELA is associated with higher levels of T cell senescence in healthy participants. Not only did we find a higher number of senescent cells (CD57+), these cells also expressed higher levels of CD57, a cell surface marker for senescence, and were more cytotoxic in ELA compared to controls. Control participants with high CMV titers showed a higher number of senes...
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We present a case of amyloidosis AL with isolated myocardial involvement. Because of a refractory heart failure picture, patient underwent orthotopic heart transplant (OHT). The replaced heart showed an important midwall infiltration. Ten months after he underwent autologous stem-cell transplantation (ASCT) with a favorable outcome. The case demonstrates that OHT followed by ASCT in highly selected patients with light chain amyloidosis is a life-saving procedure.
Conclusions Immunomodulatory effects of AZD2014, unlike those of RAPA, were not sustained after drug withdrawal, possibly reflecting distinct pharmacokinetics or/and inhibitory effects of AZD2014 on mTORC2.
Conclusions Our data demonstrated that circulating leukocytes derived from donor lungs, and not circulating proinflammatory cytokines substantially impaired the quality of lung grafts through caspase-1–induced pyroptotic cell death during EVLP. Removing these cells with a LF and/or inhibiting pyroptosis of the cells can be a new therapeutic approach leading to long-term success after lung transplantation.
Publication date: Available online 11 November 2017 Source:Revista Española de Cardiología (English Edition)
A Chicago bioprinting startup that seeks to 3-D print human hearts for transplantation has added to its scientific advisory board of heavy hitters. But its CEO won’t say how close the company is to producing its first viable heart. Biolife4D just announced it has added regenerative biomaterials expert Adam Feinberg, PhD to lead its scientific advisory team. Feinberg is associate professor of materials science &engineering and biomedical engineering at Carnegie Mellon University and principal investigator of the regenerative biomaterials and therapeutics group. Feinberg uses materials-based enginee...