Introduction: Translational Immunology in Kidney Disease

In April 2016, the International Society of Nephrology held a Nexus meeting in Berlin, Germany, on translational aspects of immune-mediated kidney diseases. It was believed that such a meeting was needed to discuss the hurdles blocking therapeutic advances in the field. During a time when other medical disciplines are expanding treatment options for important diseases rapidly, the kidney field still awaits major breakthroughs in therapy. It was believed that hurdles exist at several levels including inadequate animal models, methods to identify patients by central pathomechanisms rather than by histopathologic lesions, the lack of rare disease collaborative networks, the design of clinical trials, and trial end points that predict meaningful clinical outcomes.

Source: Seminars in Nephrology - August 29, 2017 Category: Urology & Nephrology Authors: Hans-Joachim Anders, David Jayne, Brad Rovin Source Type: research