ESC: Unexpected Results with Direct Thrombin Inhibitor in PCI (CME/CE)

(MedPage Today) -- Bivalirudin doesn't reduce bleeding in registry-based VALIDATE-SWEDEHEART
Source: MedPage Today Cardiovascular - Category: Cardiology Source Type: news

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Objective: To examine the relationship between menopausal status and mental well-being, and whether this relationship varies as a function of physical activity (PA). Methods: Based on a hormonal analysis and bleeding diary, women aged 47 to 55 were categorized as pre (n = 304), early peri (n = 198), late peri (n = 209), or postmenopausal (n = 387). Mental well-being was assessed using the Centre for Epidemiologic Studies Depression Scale, the International Positive and Negative Affect Schedule Short Form, and the Satisfaction with Life Scale. PA was self-reported and categorized as low, medium, and hig...
Source: Menopause - Category: OBGYN Tags: Original Studies Source Type: research
Objective: The aim of the study was to evaluate the effect of a single-capsule 17β-estradiol/progesterone (E2/P4), TX-001HR, on endometrial safety, to report on amenorrhea and bleeding patterns of users, and to identify predictors of amenorrhea. Methods: The REPLENISH trial (NCT01942668) evaluated use of TX-001HR in menopausal women (40-65 y) with vasomotor symptoms (VMS) and a uterus. Women were randomized to daily E2/P4 (mg/mg: 1/100, 0.5/100, 0.5/50, or 0.25/50), or placebo for 12 months. Incidence rate of endometrial hyperplasia was calculated from endometrial biopsies conducted at screening and study complet...
Source: Menopause - Category: OBGYN Tags: Original Studies Source Type: research
European Journal of Heart Failure, EarlyView.
Source: European Journal of Heart Failure - Category: Cardiology Authors: Tags: Research Letter Source Type: research
We characterized the biologic background of prothrombotic platelet function in the setting of durable left ventricular assist devices (LVADs) evaluating the role of different antithrombotic regimens. Platelet-mediated thrombin generation was quantified using the Platelet Activity State (PAS) Assay and the Thrombin Generation Test (TGT) in 78 patients implanted with the HeartMate II (n = 10, 13%), the HeartMate 3 (HM3) (n = 30, 38%), or the HVAD (n = 38, 49%) and managed with oral anticoagulation plus aspirin (n = 46, 59%) or anticoagulation alone (n = 32, 41%). Coagulation parameters (platelet count, International Normaliz...
Source: ASAIO Journal - Category: Medical Devices Tags: Adult Circulatory Support Source Type: research
AbstractObjectivesCentral or peripheral venoarterial extracorporeal membrane oxygenation (va ECMO) is widely used in postcardiotomy cardiogenic shock (PCS). Available data suggest controversial results for both types. Our aim was to investigate PCS patients treated with either peripheral (pECMO) or central ECMO (cECMO) concerning their outcome.MethodsBetween April 2006 and October 2016, 156 consecutive patients with va ECMO therapy due to PCS were identified and included in this retrospective analysis. Patients were divided into cECMO and pECMO groups. Statistical analysis of risk factors concerning 30 ‐day mortality of ...
Source: Journal of Cardiac Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: ORIGINAL ARTICLE Source Type: research
ConclusionIn ENSURE-AF, thromboembolic events were rare and absolute bleeding event rates were higher with concomitant APT. These findings may be relevant for AF-patients considered for dual therapy; even for a short treatment duration of 1  month.
Source: Clinical Research in Cardiology - Category: Cardiology Source Type: research
Prophylactic endoscopic clipping does not prevent delayed postpolypectomy bleeding (DPPB) and should not be used routinely in most patients, according to a new review of medical records.Reuters Health Information
Source: Medscape General Surgery Headlines - Category: Surgery Tags: General Surgery News Source Type: news
CONCLUSIONS: TAMIS is an innovative technique that may be considered for the treatment of benign diseases like anastomotic complications, benign rectal stenosis, anastomotic explorations with lavage and drainage, rectal ulcus, and rectal intussusception. It can be used to search for a good plane of dissection, which cannot be found through the abdominal anterior approach. It can also be adopted for removal of early malignant rectal polyps and for TaTME. The technique described here allows the surgeons to work under ergonomic conditions, with completely reusable materials, and with a magnified view of the operative field, a...
Source: Surgical Technology International - Category: Surgery Tags: Surg Technol Int Source Type: research
The bleeding risk went up in such patients on oral anticoagulation who then added clopidogrel in POPULAR-TAVI, and being on OAC alone didn't raise ischemic risk. Some experts question its methods.Medscape Medical News
Source: Medscape General Surgery Headlines - Category: Surgery Tags: Cardiology News Source Type: news
Conclusion: Various therapeutic bronchoscopic interventions, including combined modalities, provide rapid and sustained improvements in symptoms, respiratory status, exercise capacity, and quality of life in malignant CAO and have a good safety profile.
Source: Journal of Bronchology and Interventional Pulmonology - Category: Respiratory Medicine Tags: Original Investigations Source Type: research
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