Differential effect of cigarette smoke exposure on exhaled nitric oxide and blood eosinophils in healthy and asthmatic individuals
Background: Tobacco smoking affects both the fraction of exhaled nitric oxide (FeNO) and blood
eosinophil (B-Eos) count, two clinically useful biomarkers in respiratory disease that represent
local and systemic type-2 inflammation, respectively. Objective: We aimed to study the influence of
objectively measured smoke exposure on FeNO and B-Eos in a large population of subjects with and
without asthma. Methods: We utilized the US National Health and Nutrition Examination Surveys
2007 –2012 and included 10 669 subjects aged 6–80 years: 9869 controls and 800 asthmatics. Controls
were defined as having no respiratory disease, no hay fever in the past year, and B-Eos count ≤0.3 ×
10 9 l −1 . Asthma was defined as self-reported current asthma and at least one episode of wheezing
or an asthma attack in the past year, but no emphysema or chronic bronchitis. Tobacco use was
collected via questionnaires and serum cotinine was measured with mass spec...
Source: Journal of Breath Research - Category: Respiratory Medicine Authors: Tiago Jacinto, Andrei Malinovschi, Christer Janson, Jo ão Fonseca and Kjell Alving Source Type: research
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