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Uncommon Occurrence of Lip Squamous Cell Carcinoma in a Pediatric Patient

Source: Journal of Dentistry for Children - Category: Dentistry Authors: Tags: Case Reports Source Type: research

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ABSTRACT Deciphering the complex milieu that makes up the tumor microenvironment (TME) and the signaling engaged by TME cytokines continues to provide novel targets for therapeutic intervention. The IL‐6 family member Oncostatin M (OSM) has recently emerged as a potent driver of tumorigenesis, metastasis and therapy failure, molecular programs most frequently attributed to IL‐6 itself. In a recent issue of The Journal of Pathology, Kucia‐Tran et al. describe how elevated Oncostatin M receptor (OSMR) expression results in a feed‐forward loop involving the de novo production of both OSM and OSMR to facilitate aggress...
Source: The Journal of Pathology - Category: Pathology Authors: Tags: Invited Commentary Source Type: research
ConclusionIt is feasible and safe to use this novel, flexible, single‐arm robot in performing a transoral robotic radical tonsillectomy and retropharyngeal lymph node dissection.
Source: Head and Neck - Category: ENT & OMF Authors: Tags: OPERATIVE TECHNIQUES Source Type: research
Conclusions: Platinum-based anti-tumor-therapy reduces the number of adenosine-producing B cells and, consequently, potential immunosuppression within the tumor environment. Breg function in terms of ADO production and their potential capacity to suppress CD4+ T cells are promoted by methotrexate treatment amplifying anti-inflammatory therapeutic effects. Our results add to the understanding of how chemotherapeutic drugs can influence the human immune system and may therefore help to orchestrate standard oncologic therapy with new immune modulating approaches. Methods: Mononuclear cells were collected prospectively fro...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Authors: Ansari SS, Sharma AK, Zepp M, Ivanova E, Bergmann F, König R, Berger MR Abstract The TCGA database was analyzed to identify deregulation of cell cycle genes across 24 cancer types and ensuing effects on patient survival. Pan-cancer analysis showed that head and neck squamous cell carcinoma (HNSCC) ranks amongst the top four cancers showing deregulated cell cycle genes. Also, the median gene expression of all CDKs and cyclins in HNSCC patient samples was higher than that of the global gene expression. This was verified by IHC staining of CCND1 from HNSCC patients. When evaluating the quartiles with hig...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
We report a 75‐year‐old woman with PCH in a multifocal C‐ALCL located on the scalp and right retroauricular area, which rapidly responded to treatment with psoralen ultraviolet A photochemotherapy. Comprehensive virological analyses for potential oncogenic viruses, including Epstein–Barr virus, human herpesvirus‐8, human papillomaviruses, the recently discovered cutavirus and nine different human polyomaviruses, were negative.
Source: Clinical And Experimental Dermatology - Category: Dermatology Authors: Tags: Concise Report Source Type: research
Conclusion: Pulmonary tumor embolism should be considered when patients with malignant disease develop unexplained dyspnea, hypoxemia, and pulmonary hypertension.
Source: In Vivo - Category: Research Authors: Tags: Clinical Studies Source Type: research
ConclusionSelected stage IV achalasia patients with recurrent and disabling symptoms after previously failed Heller myotomy and/or endoscopic treatments should be offered minimally invasive esophagectomy.
Source: European Surgery - Category: Surgery Source Type: research
Abstract Radiotherapy is unlikely to benefit all patients with head and neck squamous cell carcinoma (HNSCC). Therefore, novel method is warranted to predict the radiotherapy response. Our study aimed to construct a microRNA (miRNA)‐based nomogram to predict clinical outcomes of patients with HNSCC receiving radiotherapy. We screened out 56 differential miRNAs by analyzing 44 paired tumor and adjacent normal samples miRNA expression profiles from The Cancer Genome Atlas (TCGA). A total of 307 patients with HNSCC receiving adjuvant radiotherapy were randomly divided into a training set (n = 154) and a validation...
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: Original Research Source Type: research
Conclusion In conclusion, the long term use of PPIs is associated with increased risk of oesophageal adenocarcinoma in the absence of other risk factors. Long term use of PPIs should be addressed with caution.
Source: Cancer Epidemiology - Category: Cancer & Oncology Source Type: research
Abstract: Pigmented squamous cell carcinoma in situ (pSCCis) is difficult to diagnose based on clinical and dermoscopic examination. Reflectance confocal microscopy (RCM) allows noninvasive differentiation between malignant and benign pigmented skin lesions. We determined the frequency of key RCM features of pSCCis and correlated the RCM criteria with the corresponding dermoscopic and histopathologic criteria. The study included 28 lesions with biopsy-proven diagnosis of pSCCis derived from 28 patients. Clinical, dermoscopic, and RCM images of these lesions were retrospectively analyzed by 3 independent observers. Assess...
Source: The American Journal of Dermatopathology - Category: Pathology Tags: Original Study Source Type: research
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