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Uncommon Occurrence of Lip Squamous Cell Carcinoma in a Pediatric Patient

Source: Journal of Dentistry for Children - Category: Dentistry Authors: Tags: Case Reports Source Type: research

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Nonmelanoma skin cancer is the most common cancer in humans, comprising mainly basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). BCC proliferation is highly dependent on the Hedgehog signaling pathway. We aimed to investigate a panel of anticancer drugs with known activity against skin cancer for their therapeutic potential in localized, enhanced topical treatment of SCC and BCC. Cytotoxicity profiles for vismodegib, 5-fluorouracil (5-FU), methotrexate (MTX), cisplatin, bleomycin, and vorinostat were established in terms of half maximal inhibitory concentration values in a panel of immortalized keratinocytes (H...
Source: Anti-Cancer Drugs - Category: Cancer & Oncology Tags: Preclinical Reports Source Type: research
We present a case of HPV positive tonsillar SCC of a 42‐year‐old male that initially manifested as a cystic neck mass expressing CK7, CK19, and p16 in primary and metastatic tumors. Immunohistochemical examination revealed diffuse CK19 and p16 expression, and patchy CK7 expression in the solid components of primary and metastatic tumors. However, in cystic components of metastatic tumors the expression of CK7 and CK19 was preserved but p16 expression was absent, which was consistent with immunocytochemical findings of fine‐needle aspirates from cystic neck mass. In immunocytochemistry performed on aspirates of a bran...
Source: Diagnostic Cytopathology - Category: Pathology Authors: Tags: BRIEF REPORT Source Type: research
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Source: International Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Research Article Source Type: research
In conclusion, Nrf2 regulates cancer behaviors and Notch signaling in OSCC cells. PMID: 28821430 [PubMed - indexed for MEDLINE]
Source: Biochemical and Biophysical Research communications - Category: Biochemistry Authors: Tags: Biochem Biophys Res Commun Source Type: research
This cohort study examines the use of local excision among patients with T1 squamous cell carcinoma of the anal canal and compares the overall survival relative to those who received standard treatment with chemoradiotherapy.
Source: JAMA Surgery - Category: Sports Medicine Source Type: research
Conclusion The characteristics of the patients and tumors treated by MMS are similar to those reported for similar studies in other geographic areas. Lentigo maligna and dermatofibrosarcoma protuberans accounted for a higher proportion of cases in our series, and repair of the surgical defect by a dermatologist was also more common. Operating times in MMS are not much longer than those reported for other procedures and the rate of intraoperative complications is very low.
Source: Actas Dermo-Sifiliograficas - Category: Dermatology Source Type: research
Conclusions BQ chewers carrying the T allele or C/T + T/T genotypes in pri-mir-26a-1 may have a decreased risk of oral leukoplakia, OPLs, and advanced-stage OSCC.
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - Category: ENT & OMF Source Type: research
ConclusionThis large population‐based study investigating risks of developing a different subsequent cutaneous malignancy showed high‐cumulative risks of mainly KC and markedly increased relative and absolute risks of all tumour combinations. These estimates confirm a common carcinogenesis and can serve as a base for follow‐up guidelines and patient education aiming for an early detection of the subsequent cancers.
Source: Journal of the European Academy of Dermatology and Venereology - Category: Dermatology Authors: Tags: Original Article Source Type: research
We examined associations between cSCC invasiveness and 23 reported SNPs among 67,833 non-Hispanic white subjects. Additionally, we performed a genome-wide scan and identified one SNP with significantly different frequencies in 5,724 subjects with at least one invasive tumor and 1,943 subjects with in-situ tumors only.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Original Article Source Type: research
CONCLUSIONS: Exenteration appears to be life-saving in children with orbital extension of retinoblastoma. While patients exenterated for malignant eyelid tumors have the best chance of survival, those with orbital extension of uveal melanoma and adenoid cystic carcinoma of the lacrimal gland have the worst prognosis. PMID: 29039986 [PubMed - as supplied by publisher]
Source: Orbit - Category: Opthalmology Authors: Tags: Orbit Source Type: research
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