Uncommon Occurrence of Lip Squamous Cell Carcinoma in a Pediatric Patient

Source: Journal of Dentistry for Children - Category: Dentistry Authors: Tags: Case Reports Source Type: research

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Authors: Peris K, Alaibac M, Argenziano G, Di Stefani A, Fargnoli MC, Frascione P, Gualdi G, Longo C, Moscarella E, Naldi L, Pellacani G, Pimpinelli N, Quaglino P, Salgarello M, Sollena P, Valentini V, Zalaudek I, Calzavara Pinton PG, Italian Group of Dermato-oncology (GIDO) of SIDeMaST PMID: 29898593 [PubMed - as supplied by publisher]
Source: Giornale Italiano di Dermatologia e Venereologia - Category: Dermatology Tags: G Ital Dermatol Venereol Source Type: research
In this study, we detected TNFR2 expression in ESCC tissues using IHC. The χ2 test showed that TNFR2 was positively correlated with invasion depth, advanced clinical stage and low differentiation; survival analysis showed that TNFR2 was positively correlated with poor OS; univariate Cox regression analysis showed that clinical stage, lymph node involvement and invasion de pth were all correlated with OS; multivariate Cox regression analysis showed that lymph node involvement and invasion depth were independent prognostic factors.
Source: Human Pathology - Category: Pathology Authors: Tags: Original contribution Source Type: research
ConclusionDCF chemotherapy alone had a substantial therapeutic effect on SESCC in all cases. However, despite the normal appearance of the mucosal surface, viable cancer cells remained below the basal layer of mucosa. Careful attention should be paid when diagnosing clinical CR, or securing a resection margin of SESCC after DCF chemotherapy.
Source: Esophagus - Category: Gastroenterology Source Type: research
In conclusion, miR‑20a‑5p functioned as an oncogene in HNSCC by downregulating TNFRSF21 and subsequently, upregulating CCR7 expression. PMID: 29901115 [PubMed - as supplied by publisher]
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Authors: Ghasemi F, Black M, Sun RX, Vizeacoumar F, Pinto N, Ruicci KM, Yoo J, Fung K, MacNeil D, Palma DA, Winquist E, Mymryk JS, Ailles LA, Datti A, Barrett JW, Boutros PC, Nichols AC Abstract Head and neck squamous cell carcinoma (HNSCC) is a common cancer diagnosis worldwide. Despite advances in treatment, HNSCC has very poor survival outcomes, emphasizing an ongoing need for development of improved therapeutic options. The distinct tumor characteristics of human papillomavirus (HPV)-positive vs. HPV-negative disease necessitate development of treatment strategies tailored to tumor HPV-status. High-throughput r...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Conclusions: The results of the present study suggest that reductions in AE2 in ESCC enhance cellular movement by activating MMP signaling pathways and are related to a poor prognosis in patients with ESCC. Methods: In human ESCC cell lines, knockdown experiments were conducted using AE2 siRNA, and the effects on cellular movement and survival were analyzed. The gene expression profiles of cells were examined using a microarray analysis. An immunohistochemical analysis was performed on 61 primary tumor samples obtained from ESCC patients who underwent esophagectomy. PMID: 29899837 [PubMed]
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Sipi soup inhibits cancer‑associated fibroblast activation and the inflammatory process by downregulating long non‑coding RNA HIPK1‑AS. Mol Med Rep. 2018 Jun 06;: Authors: Zhou B, Yu Y, Yu L, Que B, Qiu R Abstract Sipi soup (SPS), the aqueous extract derived from the root bark of Sophora japonical L, Salix babylonica L., Morus alba L., as well as Amygdalus davidiana (Carr.) C. de Vos, is a traditional Chinese medicine frequently used to prevent and treat infection and inflammation. However, the role of SPS in cancer‑associated fibroblasts (CAFs) require further investigation. In the present stu...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Long noncoding RNA AFAP1‑AS1 enhances cell proliferation and invasion in osteosarcoma through regulating miR‑4695‑5p/TCF4‑β‑catenin signaling. Mol Med Rep. 2018 Jun 05;: Authors: Li R, Liu S, Li Y, Tang Q, Xie Y, Zhai R Abstract Long noncoding RNA AFAP1‑AS1 has been shown to promote tumor progression in several human cancer types, such as thyroid cancer, tongue squamous cell carcinoma and lung cancer. However, the role of AFAP1‑AS1 in osteosarcoma (OS) has not been investigated. In the present study, the expression of AFAP1‑AS1 was significantly upregulated in OS tissues and cell l...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
To the Editor: We read with interest the paper by Que SKT et  al regarding the management of cutaneous squamous cell carcinoma (cSCC)1 and the remarkable discussion about the field treatment with topical chemotherapy agents. Imiquimod is an immune response modifier that activates immune cells via toll-like receptor 7, initiating a cascade leading to the indu ction of cytokines, such as interferon alfa, interferon gamma, and interleukin 12, which promote a T helper 1 (TH1) immune response.2 The use of imiquimod for the treatment of invasive cSCC is not approved by the European Medicines Agency or Food and Drug Administ...
Source: Journal of the American Academy of Dermatology - Category: Dermatology Authors: Tags: JAAD online Source Type: research
To the Editor: We read with interest the article by Gonzalez-Guerrero et  al1 reporting the prognostic significance of tumor buds in cutaneous squamous cell carcinoma (cSCC). The results of this study confirm and complement the results of 2 similar investigations published previously on the same topic,2,3 even though the methodology of these 3 studies was not identical. In our study,2 we compared 31 aggressive cSCCs, defined as tumors with subsequent local recurrences or metastases, with 21 nonaggressive cSCCs (which had been obtained from the same group of organ-graft recipients) and counted the number of tumor buds ...
Source: Journal of the American Academy of Dermatology - Category: Dermatology Authors: Tags: JAAD online Source Type: research
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