A central neural circuit for itch sensation

Although itch sensation is an important protective mechanism for animals, chronic itch remains a challenging clinical problem. Itch processing has been studied extensively at the spinal level. However, how itch information is transmitted to the brain and what central circuits underlie the itch-induced scratching behavior remain largely unknown. We found that the spinoparabrachial pathway was activated during itch processing and that optogenetic suppression of this pathway impaired itch-induced scratching behaviors. Itch-mediating spinal neurons, which express the gastrin-releasing peptide receptor, are disynaptically connected to the parabrachial nucleus via glutamatergic spinal projection neurons. Blockade of synaptic output of glutamatergic neurons in the parabrachial nucleus suppressed pruritogen-induced scratching behavior. Thus, our studies reveal a central neural circuit that is critical for itch signal processing.
Source: ScienceNOW - Category: Science Authors: Tags: Neuroscience reports Source Type: news

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Publication date: 19 September 2018Source: Neuron, Volume 99, Issue 6Author(s): Lindsey M. Snyder, Michael C. Chiang, Emanuel Loeza-Alcocer, Yu Omori, Junichi Hachisuka, Tayler D. Sheahan, Jenna R. Gale, Peter C. Adelman, Elizabeth I. Sypek, Stephanie A. Fulton, Robert L. Friedman, Margaret C. Wright, Melissa Giraldo Duque, Yeon Sun Lee, Zeyu Hu, Huizhen Huang, Xiaoyun Cai, Kimberly A. Meerschaert, Vidhya Nagarajan, Toshiro HiraiSummaryPrimary afferents are known to be inhibited by kappa opioid receptor (KOR) signaling. However, the specific types of somatosensory neurons that express KOR remain unclear. Here, using a newl...
Source: Neuron - Category: Neuroscience Source Type: research
-- It's every parent's nightmare -- diaper rash that causes itchy bumps, scaly skin and lots of discomfort for your baby. The Nemours Foundation says you can help prevent diaper rash by keeping the infant's skin dry and clean. If your child develops...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
ConclusionsCutaneous larva migrans is an endemic disease with predilection for poor and vulnerable persons. Preventive efforts such as wearing of slippers, usage of drying lines, and deworming of pets are crucial in preventing the occurrence of this disease and should be encouraged.
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
Conditions:   Pruritus;   Prurigo Nodularis Interventions:   Drug: 5mg Serlopitant Tablets;   Drug: Placebo Tablets Sponsor:   Menlo Therapeutics Inc. Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
WEDNESDAY, Sept. 19, 2018 -- Eczema, or atopic dermatitis, can be very difficult to control in some people. But the skin condition, which leads to dry, itchy and inflamed skin, is particularly problematic for black people, according to new...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
Conditions:   Pruritus;   Prurigo Nodularis Interventions:   Drug: 5mg Serlopitant Tablets;   Drug: Placebo Tablets Sponsor:   Menlo Therapeutics Inc. Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
ConclusionResults demonstrate a substantial disease burden on psoriasis patients in Russia, despite receiving treatment for their psoriasis, as well as low patient/dermatologist concordance of views on treatment outcomes. These findings also highlight a need to further incorporate the patient ’s views into treatment decision-making in Russia.FundingNovartis Pharma AG, Basel, Switzerland.
Source: Dermatology and Therapy - Category: Dermatology Source Type: research
AbstractBackgroundMorphea can lead to considerable cosmetic or functional impairment; nevertheless, health-related quality of life (HRQoL) is rarely documented in adult morphea patients.ObjectiveTo investigate the impact of morphea on HRQoL and to identify determinants of impaired HRQoL.MethodsA cross-sectional study has been carried out among adult morphea patients. HRQoL was evaluated by the Dermatology Life Quality Index (DLQI). The modified Localised Scleroderma Skin Severity Index (mLoSSI) and the Localised Scleroderma Damage Index (LoSDI) were applied to evaluate disease activity and damage, respectively. Physician G...
Source: Quality of Life Research - Category: Health Management Source Type: research
Abstract The interactions between plants and their herbivores are highly complex systems generating on one side an extraordinary diversity of plant protection mechanisms and on the other side sophisticated consumer feeding strategies. Herbivores have evolved complex, integrative sensory systems that allow them to distinguish between food sources having mere bad flavors from the actually toxic ones. These systems are based on the senses of taste, olfaction and somatosensation in the oral and nasal cavities, and on post-ingestive chemosensory mechanisms. The potential ability of plant defensive chemical traits to in...
Source: Pflugers Archiv : European Journal of Physiology - Category: Physiology Authors: Tags: Pflugers Arch Source Type: research
fer J Abstract Itch is an unpleasant symptom, affecting many dermatological patients. Studies investigating the occurrence and intensity of itch in dermatological patients often focus on a single skin disease and omit a control group with healthy skin. The aim of this multi-centre study was to assess the occurrence, chronicity and intensity (visual analogue scale 0-10) of itch in patients with different skin diseases and healthy-skin controls. Out of 3,530 dermatological patients, 54.3% reported itch (mean ± standard deviation itch intensity 5.5 ± 2.5), while out of 1,094 ...
Source: Acta Dermato-Venereologica - Category: Dermatology Authors: Tags: Acta Derm Venereol Source Type: research
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