A central neural circuit for itch sensation

Although itch sensation is an important protective mechanism for animals, chronic itch remains a challenging clinical problem. Itch processing has been studied extensively at the spinal level. However, how itch information is transmitted to the brain and what central circuits underlie the itch-induced scratching behavior remain largely unknown. We found that the spinoparabrachial pathway was activated during itch processing and that optogenetic suppression of this pathway impaired itch-induced scratching behaviors. Itch-mediating spinal neurons, which express the gastrin-releasing peptide receptor, are disynaptically connected to the parabrachial nucleus via glutamatergic spinal projection neurons. Blockade of synaptic output of glutamatergic neurons in the parabrachial nucleus suppressed pruritogen-induced scratching behavior. Thus, our studies reveal a central neural circuit that is critical for itch signal processing.
Source: ScienceNOW - Category: Science Authors: Tags: Neuroscience reports Source Type: news

Related Links:

ECZEMA is a condition that causes skin to become itchy, red, dry and cracked. While creams are recommended by doctors to soothe inflammation, it ’s often the case that different treatments work for different patients. For one child, a particular type of clothing helped his distressed skin. But the treatment is now under consultation and could be offered on a limited basis. 
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Updated Date: Dec 11, 2018 EST
Source: DailyMed Drug Label Updates - Category: Drugs & Pharmacology Source Type: alerts
Updated Date: Dec 11, 2018 EST
Source: DailyMed Drug Label Updates - Category: Drugs & Pharmacology Source Type: alerts
REDWOOD CITY, Calif., Dec. 10, 2018 (GLOBE NEWSWIRE) -- Menlo Therapeutics Inc. (NASDAQ: MNLO), a late-stage biopharmaceutical company focused on the development of serlopitant for the treatment of pruritus (itch), today announced positive top-line...
Source: Drugs.com - Clinical Trials - Category: Pharmaceuticals Source Type: clinical trials
Updated Date: Dec 10, 2018 EST
Source: DailyMed Drug Label Updates - Category: Drugs & Pharmacology Source Type: alerts
ConclusionModerate-to-severe AD is associated with significant decrements of health utility in the US population. These data illustrate the heavy societal burden of moderate and severe AD and provide important insight for prioritization of resource allocation and cost-effectiveness research.
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
This study laid the foundation for the application of EPS as an emulsifier and highlighted the application prospects of EPS in topical emulsion. PMID: 30537504 [PubMed - as supplied by publisher]
Source: International Journal of Biological Macromolecules - Category: Biochemistry Authors: Tags: Int J Biol Macromol Source Type: research
Betsy Ambooken, Neelakandhan Asokan, KT Jisha, Lincy NinanIndian Journal of Sexually Transmitted Diseases and AIDS 2018 39(2):130-132Palmoplantar lesions of secondary syphilis are often termed “syphilis cornee.” A 32-year-old male presented with itchy lichenoid papules on both soles and left palm associated with grayish white papules on the buccal mucosa and glans penis. Initial clinical diagnosis of palmoplantar lichen planus with mucosal involvement was supported by the histopathological finding of interface dermatitis. However, more detailed history, serological tests of syphilis, and review of histopatholog...
Source: Indian Journal of Sexually Transmitted Diseases - Category: Infectious Diseases Authors: Source Type: research
ConclusionWe concluded that the Itch Man Scale has promising validity and is a user-friendly tool to use in clinical practice to determine the itch intensity in children younger than 13 years in a South African setting.
Source: Burns - Category: Dermatology Source Type: research
Updated Date: Dec 6, 2018 EST
Source: DailyMed Drug Label Updates - Category: Drugs & Pharmacology Source Type: alerts
More News: Brain | Gastroenterology | Itchiness | Neurology | Opthalmology | Study