Comparison of vernakalant and ranolazine in atrial fibrillation

Background: Current guidelines recommend vernakalant for pharmacologic cardioversion of recent-onset atrial fibrillation. However, this drug is not established as chronic therapy. Methods and results: In total, 15 rabbit hearts were Langendorff-perfused. A burst pacing protocol-induced atrial fibrillation in 7 of 15 hearts at baseline (10 episodes). Subsequently, a combination of acetylcholine and isoproterenol (ACH/ISO) has been administered to increase occurrence of atrial fibrillation resulting in a reduction of atrial action potential duration (−25 ms, P 
Source: Journal of Cardiovascular Medicine - Category: Cardiology Tags: Research articles: Atrial arrhythmias Source Type: research