Intracellular iron overload leading to DNA damage of lymphocytes and immune dysfunction in thalassemia major patients

ConclusionTherefore, intracellular iron overload caused DNA fragmentation which may ultimately hamper lymphocyte function and this may contribute to immune dysfunction and increased susceptibility to infections in thalassemia patients as indicated by the good correlation (R2=0.91) between lymphocyte DNA damage and rate of infection found in the present study.This article is protected by copyright. All rights reserved.

Source: European Journal of Haematology - August 1, 2017 Category: Hematology Authors: Jyoti Shaw, Ayan Chakraborty, Arijit Nag, Arnab Chattopadyay, Anjan Kr Dasgupta, Maitreyee Bhattacharyya Tags: Original Article Source Type: research