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Antibiotic Doesn't Prevent Lung Complication After Stem Cell Transplant

Title: Antibiotic Doesn't Prevent Lung Complication After Stem Cell TransplantCategory: Health NewsCreated: 8/8/2017 12:00:00 AMLast Editorial Review: 8/9/2017 12:00:00 AM
Source: MedicineNet Lungs General - Category: Respiratory Medicine Source Type: news

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In this study, we have shown that the lipid chaperones FABP4/FABP5 are critical intermediate factors in the deterioration of metabolic systems during aging. Consistent with their roles in chronic inflammation and insulin resistance in young prediabetic mice, we found that FABPs promote the deterioration of glucose homeostasis; metabolic tissue pathologies, particularly in white and brown adipose tissue and liver; and local and systemic inflammation associated with aging. A systematic approach, including lipidomics and pathway-focused transcript analysis, revealed that calorie restriction (CR) and Fabp4/5 deficiency result ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
In this study, we report successful decellularization of human livers to obtain transplantable whole organ scaffolds. We show proof of concept that these scaffolds can serve as feasible resources for future tissue-engineering purposes. Using a controlled perfusion system, a complete 3D acellular human liver scaffold was generated on a clinically relevant scale and free of allo-antigens. We present the feasibility of systematically upscaling the decellularization process to discarded human livers. Eleven human livers were efficiently decellularized by nonionic detergents by machine perfusion. A careful choice of the decellu...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs
Abstract PC are a main cause of death following HSCT in children. We aimed to evaluate early predictors of mortality in paediatric recipients with PCs. A retrospective observational study of 35 patients with 49 episodes of PI on chest radiography (of 124 patients) who had undergone HSCT at a tertiary university hospital between January 2011 and December 2012 was performed. During follow‐up (median 26.1 months), 15 episodes led to death (30.6%). An aetiologic diagnosis was made by non‐invasive tests in 24 episodes (49.0%) and by adding bronchoalveolar lavage and/or lung biopsy in 7 episodes with diagnostic yield (7...
Source: Pediatric Transplantation - Category: Transplant Surgery Authors: Tags: ORIGINAL ARTICLE Source Type: research
d C PMID: 28992651 [PubMed - as supplied by publisher]
Source: The Thoracic and Cardiovascular Surgeon - Category: Cardiovascular & Thoracic Surgery Authors: Tags: Thorac Cardiovasc Surg Source Type: research
The modern era of transplantation began in the 1954 when Dr Murray performed the first successful kidney transplant operation. Just 2 years later, Dr Thomas and colleagues performed the first successful bone marrow transplant procedure. Both physicians received the Nobel Prize in physiology or medicine in 1990 for their groundbreaking work. In the 1960s, the first liver, heart, and lung transplant procedures were performed, with most patients experiencing suboptimal outcomes. Since then, outcomes have steadily improved.
Source: Clinics in Chest Medicine - Category: Respiratory Medicine Authors: Tags: Preface Source Type: research
This article is protected by copyright. All rights reserved. Hypothetical mode of action of mMSC versus extracellular vesicles after i.v. injection into lethally irradiated mice. (A) mMSC accumulate in the lung after i.v. injection into lethally irradiated recipients. There, a polarization of tissue resident and immigrating macrophages takes place, changing the pro‐inflammatory environment after irradiation into an anti‐inflammatory one. Although mMSC were trapped in the lung, decreased inflammation, oxidative stress and apoptosis as well as enforced cell cycle in the bone marrow have been detected. (B) Mouse MSC‐de...
Source: Stem Cells - Category: Stem Cells Authors: Tags: Regenerative Medicine Source Type: research
Conclusion Vaccine companies have regularly used blood and body parts from killed cows, dogs, worms, mice, chickens, human babies, monkeys, guinea pigs, rabbits, hamsters, rats, etc., to make these vaccines, so using foreskin from newborn babies may not surprise some. For many, it is appalling. [28] Circumcisions fuel multi-billion dollar industries. If you see neonatal foreskin for sale, which is very easy to find on the internet, remember that these newborn children didn’t consent to being circumcised and they didn’t consent for their foreskin to be sold, used for research purposes, or to be injected into the...
Source: vactruth.com - Category: Allergy & Immunology Authors: Tags: Augustina Ursino Top Stories circumcision truth about vaccines Source Type: blogs
Abstract We investigated the effect of repeated remote ischaemic post-conditioning (RIPoC) on the organ distribution of the intramyocardially injected MSCs in rat myocardial ischemia model. Myocardial ischemia of adult female Sprague-Dawley rats was induced by 30-min. obstruction of the left anterior descending coronary artery. Repeated RIPoC was induced after ischemia with three cycles of 5-min. occlusion and reperfusion of the limb with the frequency of half a day, 1 or 2 days, respectively. Compared with that by single RIPoC, repeated RIPoC transiently reduced oxidative stress, lipid peroxidation and infla...
Source: J Cell Mol Med - Category: Molecular Biology Authors: Tags: J Cell Mol Med Source Type: research
Abstract We investigated the effect of repeated remote ischaemic post‐conditioning (RIPoC) on the organ distribution of the intramyocardially injected MSCs in rat myocardial ischemia model. Myocardial ischemia of adult female Sprague‐Dawley rats was induced by 30‐min. obstruction of the left anterior descending coronary artery. Repeated RIPoC was induced after ischemia with three cycles of 5‐min. occlusion and reperfusion of the limb with the frequency of half a day, 1 or 2 days, respectively. Compared with that by single RIPoC, repeated RIPoC transiently reduced oxidative stress, lipid peroxidation and inflam...
Source: Journal of Cellular and Molecular Medicine - Category: Molecular Biology Authors: Tags: Original Article Source Type: research
Authors: Kloth C, Thaiss WM, Hetzel J, Bier G, Wirths S, Nikolaou K, Horger M Abstract BACKGROUND: To quantify lung parenchymal changes in symptomatic patients with chronic pulmonary graft-versus-host disease 3 years after allogeneic stem cell transplantation (allo-SCT) by means of CT-densitometry (CTD) and to compare results with those of established pulmonary function tests (PFT). METHODS: The study group consisted of 26 patients with pulmonary cGvHD (19 males, 7 females; mean age, 49.29±15.89; range, 19-72 years). The diagnosis was based on clinical symptoms, PFT and chest-CT findings. CTD and PFT wer...
Source: Journal of Thoracic Disease - Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research
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