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Higher risk for celiac disease in diabetic children

(Reuters Health) - - Celiac disease (CD) is more common in young people with type 1 diabetes than in diabetes-free kids, although how often the two conditions occur together varies in different countries, a new study finds.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news

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AbstractAimTo investigate the association of alleles of the 3 ′ immunoglobulin heavy-chain regulatory region 1 (3′RR-1) enhancer hs1.2 in patients with type 1 diabetes (T1D).MethodsEighty-one patients with T1D [among which 12 had concomitant coeliac disease (CD) and 25 an autoimmune thyroid disease (AITD)] were compared to 248 healthy individuals. All subjects were recruited from the same geographical area. Blood samples were collected from all patients and a nested PCR was performed to amplify the core of the 3 ′RR-1 and detect the alleles of the hs1.2 enhancer.ResultsAllele distribution in healthy indiv...
Source: Acta Diabetologica - Category: Endocrinology Source Type: research
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Source: Clinical and Experimental Immunology - Category: Allergy & Immunology Authors: Tags: Original Article Source Type: research
ConclusionsCollectively, GF diet administered during pregnancy improves signs of celiac disease and autoimmune diabetes in the offspring. The diabetes‐ameliorative effect of GF diet in utero is followed by dampening of inflammation, unchanged beta‐cell volume, but increased islet numbers.
Source: Diabetes/Metabolism Research and Reviews - Category: Endocrinology Authors: Tags: RESEARCH ARTICLE Source Type: research
In this study we evaluated whether co-existing autoimmune diseases had significant impact on lipid and lipoprotein subclasses, as known cardiovascular risk factors in T1DM. DESIGN AND METHODS: Study included 201 subjects with T1DM (14.1 ± 2.9 years) and 141 age- and gender-matched controls. ATD was presented in 30 and CD in 15 T1DM patients. Serum lipid parameters were determined by routine laboratory methods and plasma low-density (LDL) and high-density lipoprotein (HDL) subclasses by gradient-gel electrophoresis method. RESULTS: Both groups of T1DM patients with concomitant autoimmune disease had s...
Source: Clinical Biochemistry - Category: Biochemistry Authors: Tags: Clin Biochem Source Type: research
The opioid epidemic of the last 20 years has served to illustrate the powerful addictive properties of anything that binds to opioid receptors of the human brain. Lives are ruined by opioid addiction, more than 100 deaths now occurring every day from overdose as people either take more and more to overcome the partial tolerance or new potent drugs like fentanyl make their way into street versions. Drugs such as oxycodone, hydrocodone, and fentanyl bind to the brain’s opioid receptors provoking a “high” while causing the user to desire more opioids as partial tolerance develops. And make no mistake: Much o...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Wheat Belly Lifestyle addiction addictive eating disorder opiates opioids undoctored Source Type: blogs
Abstract In the field of inflammation imaging, nuclear medicine techniques can be considered as a non-invasive tool to early detect pathophysiological changes I affected tissues. These changes usually occur before clinical onset of symptoms and before the development of anatomical changes, that are commonly detected by radiological procedures. This is particularly important for prognostic purposes, therapy decision making and for therapy follow-up. Here we review the current state-of-theart of nuclear medicine for diagnostic purposes in different conditions characterized by a chronic inflammation, such as vulnerab...
Source: Current Pharmaceutical Design - Category: Drugs & Pharmacology Authors: Tags: Curr Pharm Des Source Type: research
CONCLUSIONS: Tests based on anti-TG IgA are more accurate for detecting CD in children with type 1 diabetes than anti-DGP IgA. A high percentage of diabetic children carry HLA alleles predisposing to CD, which indicates that genetic screening in this group of patients is not obligated. PMID: 29350070 [PubMed - as supplied by publisher]
Source: Autoimmunity - Category: Allergy & Immunology Tags: Autoimmunity Source Type: research
by Iris Broce, Celeste M. Karch, Natalie Wen, Chun C. Fan, Yunpeng Wang, Chin Hong Tan, Naomi Kouri, Owen A. Ross, G ünter U. Höglinger, Ulrich Muller, John Hardy, International FTD-Genomics Consortium , Parastoo Momeni, Christopher P. Hess, William P. Dillon, Zachary A. Miller, Luke W. Bonham, Gil D. Rabinovici, Howard J. Rosen, Gerard D. Schellenberg, Andre Franke, Tom H. Karlsen, Jan H. Veldink, Raffaele Ferr ari, Jennifer S. Yokoyama, Bruce L. Miller, Ole A. Andreassen, Anders M. Dale, Rahul S. Desikan, Leo P. Sugrue BackgroundConverging evidence suggests that immune-mediated dysfunction plays an important ro...
Source: PLoS Medicine - Category: Internal Medicine Authors: Source Type: research
Conditions:   Type 2 Diabetes Mellitus;   Celiac Disease Interventions:   Other: Acute test meal with fiber-enriched buckwheat pasta;   Other: Acute test meal with corn pasta Sponsor:   Federico II University Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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