Accuracy of a Laryngopharyngeal Endoscopic Esthesiometer (LPEER) for Evaluating Laryngopharyngeal Mechanosensitivity: A Validation Study in a Prospectively Recruited Cohort of Patients
AbstractRecent studies have shown an association between alterations in laryngopharyngeal mechanosensitivity (LPMS) and dysphagia, obstructive sleep apnea, and chronic cough hypersensitivity syndrome. A previous reliability study of a new laryngopharyngeal endoscopic esthesiometer and rangefinder (LPEER) showed high intra- and inter-rater reliability; however, its accuracy has not been tested. We performed an accuracy study of the LPEER in a prospectively and consecutively recruited cohort of 118 patients at two tertiary care university hospitals. Most of the patients were suffering from dysphagia, and all of them underwent a standard clinical evaluation and fiberoptic endoscopic evaluation of swallowing with sensory testing (FEESST) using a new sensory testing protocol. The sensory test included determinations of the laryngeal adductor reflex threshold (LART), the cough reflex threshold (CRT) and the gag reflex threshold (GRT). Abnormalities on these reflex thresholds were evaluated for associations with major alterations in swallowing safety (pharyngeal residues, penetration, and aspiration). We evaluated the discriminative capacity of the LPMS test using ROC curves and the area under the curve (AUC –ROC) and its relationship with the eight-point penetration–aspiration scale (PAS) using the Spearman’sρ correlation coefficient (SCC). We found a positive correlation between the PAS and LART (SCC 0.47;P
Researchers at Children's National Health System found chronic inflammation is vital in sustained delivery of a new treatment for Duchenne muscular dystrophy.
"Human beings are the only species that deliberately deprive themselves of sleep for no apparent gain," says sleep scientist Matthew Walker. His new book is Why We Sleep. (Image credit: MCKIBILLO/Getty Images/Imagezoo)
Authors: Al Maani A, Al Qayoudhi A, Nazir HF, Omar H, Al Jardani A, Al Muharrmi Z, Wali Y Abstract OBJECTIVES: A resurgence of pertussis or whooping cough has been observed worldwide despite broad vaccination coverage. Pertussis like illness (PLI) refers to a clinical syndrome compatible with pertussis infection but lacking laboratory confirmation or an epidemiological link to a confirmed case. Our study aimed to estimate the contribution of Bordetella pertussis infection and identifying predictors of its diagnosis in a cohort of children with PLI. METHODS: Demographic and clinical information were retrospectiv...
Conclusion: A single oral dose of VE modulates intracortical facilitatory circuits. Our results in healthy subjects could be predictive markers of treatment response in patients and further support the use of pharmaco-TMS to investigate the neuropsychiatric effects of herbal therapies in humans.Neuropsychobiology 2017;75:46-51
Conditions: Hypertensive Disorder of Pregnancy; Sleep Apnea, Obstructive Interventions: Device: Positive Airway Pressure; Device: Nasal Dilator Strip Sponsors: Dr John Kimoff; Canadian Institutes of Health Research (CIHR); ResMed Canada Inc. Not yet recruiting
Condition: Cough Interventions: Drug: BAY1817080; Drug: Matching Placebo Sponsor: Bayer Not yet recruiting
Kristen Grip stood in the middle of the basketball court, motionless. Around her, the action continued as usual — the smack of the ball on the polished wood floor, the rush of her teammates as they darted back and forth, the satisfying swish and shout of victory as someone made a basket. Yet the high school freshman stared vacantly into space, her only movement a small tap of her fingers together. Later, after the coach had blown a whistle and halted the game, Kristen learned that it had happened again: she’d had another seizure. Embarrassed and frustrated, she bid her friends farewell and headed to the school ...
By guest blogger Juliet Hodges Spreading information about the benefits of exercise – including how it reduces the risk of chronic diseases and improves mental health and wellbeing, from sleep quality to self-esteem – hasn’t been enough to change people’s behaviour. Only 30 to 40 per cent of adults in the UK say they get the recommended amount of physical activity per week, and this figure drops to just 5 per cent when using accelerometers to measure movement. It’s a similar story even for people who have made the effort to join a gym – in a recent poll, a third of members reported ...
CONCLUSION: This article presents a useful technique with low morbidity and mortality. Further investigation is needed, especially in our Mexico, where neuroendoscopical techniques are still in the development phase. PMID: 29026668 [PubMed]
CONCLUSIONS: The propofol-remifentanil combination was associated with a higher incidence of desaturation. The dexmedetomidine-remifentanil combination was associated with inadequate sedation in one half of the patients, even though it produced less respiratory depression. Addition of remifentanil reduced the cough reflex. PMID: 25643766 [PubMed - as supplied by publisher]