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Precision Medicine in Metastatic Colorectal Cancer: Relevant Carcinogenic Pathways and Targets —PART 1: Biologic Therapies Targeting the Epidermal Growth Factor Receptor and Vascular Endothelial Growth Factor

Here we review drugs that target the EGFR and VEGF pathways, focusing on patient selection, drug toxicities, and how to choose agents for first-line therapy.
Source: CancerNetwork - Category: Cancer & Oncology Authors: Tags: Colorectal Cancer Gastrointestinal Cancer Oncology Journal Review Article Source Type: news

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Abstract Patient classification through feature selection (FS) based on gene expression data (GED) has already become popular to the research communities. T-test is the well-known statistical FS method in GED analysis. However, it produces higher false positives and lower accuracies for small sample sizes or in presence of outliers. To get rid from the shortcomings of t-test with small sample sizes, SAM has been applied in GED. But, it is highly sensitive to outliers. Recently, robust SAM using the minimum β-divergence estimators has overcome all the problems of classical t-test &SAM and it has been succe...
Source: Bioinformation - Category: Bioinformatics Authors: Tags: Bioinformation Source Type: research
Authors: Abdel-Rahman O Abstract BACKGROUND: The current study tried to evaluate the factors affecting 10- to 20- years' survival among long term survivors (>5 years) of colorectal cancer (CRC) and to examine if risk of death from CRC beyond five years varies based on baseline characteristics. PATIENTS AND METHODS: Surveillance, Epidemiology and End Results (SEER) database (1988-2008) was queried through SEER*Stat program. Univariate probability of overall and cancer-specific survival was determined by the life tables' option of the SPSS and the difference between groups was examined through Wilcoxon (Gehan)...
Source: Expert Review of Anticancer Therapy - Category: Cancer & Oncology Tags: Expert Rev Anticancer Ther Source Type: research
CONCLUSIONS: The finding of a dMMR CRC had consequences for decisions on chemotherapy in a relative high proportion of patients. We recommend testing in all patients with CRC independent of age at diagnosis, as proper treatment decisions and genetic counselling are very important. PMID: 29161904 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Gastroenterology - Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research
Regorafenib, an oral multikinase inhibitor, was approved in September 2012 by the US Food and Drug Administration for the treatment of patients with metastatic colorectal cancer progressing on standard therapies. Here, we describe the clinical history of a 63-year-old male patient who was treated with regorafenib in the pivotal CORRECT trial. The patient was initially diagnosed in November 2008 with nonmetastaticKRAS-mutated (exon 2, codon 12) rectal cancer. He underwent successful surgery and was treated with 5 cycles of adjuvant chemotherapy. In 2010, lung metastases (KRAS-mutated) were detected and the patient received ...
Source: Case Reports in Oncology - Category: Cancer & Oncology Source Type: research
Authors: Gupta G, Chellappan DK, de Jesus Andreoli Pinto T, Hansbro PM, Bebawy M, Dua K Abstract MicroRNAs (miRNAs) are noncoding RNAs of around 20-25 nucleotides in length with highly conserved characteristics. They moderate posttranscriptional silencing by precisely combining with 3' untranslated regions (UTRs) of target mRNAs at a complementary site. miR503, an associate of the "canonical" miRNA16 family, is expressed in numerous types of tumors such as breast cancer, prostate cancer, lung cancer, colorectal cancer, hepatocellular carcinoma, glioblastoma and several others. There is convincing evidence...
Source: Panminerva Medica - Category: General Medicine Tags: Panminerva Med Source Type: research
Most medical professionals recommend the use of a colonoscopy to detect colon cancer, but it can be costly and invasive. Are there alternatives?
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Colorectal Cancer Source Type: news
Conclusions: Biologic importance of flat lesions is obscure, as they are usually missed during colonoscopy. The use of novel endoscopic techniques may improve their detection and diagnosis rates. PMID: 29162970 [PubMed - in process]
Source: JSLS : Journal of the Society of Laparoendoscopic Surgeons - Category: Surgery Tags: JSLS Source Type: research
Whether Fusobacterium nucleatum causes colon tumors is unknown. But a new study hints that it may be ‘ an integral part of the cancer. ’
Source: NYT Health - Category: Consumer Health News Authors: Tags: Colon and Colorectal Cancer Bacteria Tumors Dana-Farber Cancer Institute Source Type: news
Authors: Huang MY, Huang CM, Tsai HL, Huang CW, Hsieh HM, Yeh YS, Wu JY, Wang WM, Wang JY Abstract The present study aimed to demonstrate the potential advantage of oral uracil-tegafur (UFUR)/leucovorin (LV) as the subsequent therapy in patients with stage III colon cancer following adjuvant LV, 5-fluorouracil and oxaliplatin (FOLFOX4) chemotherapy. Of a total 143 patients, 62 patients received only FOLFOX adjuvant chemotherapy (FOLFOX4 biweekly × 12 cycles for 6 months), and 81 patients received FOLFOXU adjuvant treatment (which consisted of FOLFOX4 biweekly × 12 cycles for 6 months followed by oral UF...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
Authors: Chen S, Wang Y, Zhang L, Su Y, Zhang M, Wang J, Zhang X Abstract The aim of the present study was to investigate the mechanism of metastasis in colorectal cancer (CRC) using microRNA (miRNA) and mRNA expression profiles. The mRNA and miRNA expression profiles of the GSE2509 and GSE56350 datasets were obtained from the Gene Expression Omnibus database. The differentially expressed genes (DEGs) and differentially expressed miRNAs (DEMs) were identified using the limma software package. The Database for Annotation, Visualization and Integrated Discovery was used to perform Gene Ontology (GO) and Kyoto Encyclo...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
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