Precision Medicine in Metastatic Colorectal Cancer: Relevant Carcinogenic Pathways and Targets —PART 1: Biologic Therapies Targeting the Epidermal Growth Factor Receptor and Vascular Endothelial Growth Factor
Here we review drugs that target the EGFR and VEGF pathways, focusing on patient selection, drug toxicities, and how to choose agents for first-line therapy.
ConclusionExercise training is feasible in patients with colorectal cancer after completion of adjuvant chemotherapy. The main problem encountered during the study was compliance. To improve compliance of exercise training, several measures were adapted for the upcoming prospective randomized ABCSG C08 Exercise II study.
ConclusionsThis study generated qualitative data on survivorship impacts and components of survivor resilience in NZ. It also provided insights into the need for better strategies and pathways to help the NZ health system be more responsive to both M āori and non-Māori survivors.Implications for cancer survivorsSurvivor impacts create vulnerabilities that are experienced and described differently by individuals and groups in NZ. Tailored survivor support that can enhance resilience and support relationships is needed in NZ.
Authors: Jia B, Xia L, Cao F Abstract Colorectal cancer (CRC) develops from the colon or rectum and is the fourth highest inducer of cancer mortality. In the present study, cancer tissues and normal tissues were extracted from patients with CRC who were treated in the Affiliated Hospital of Shandong University of Traditional Chinese Medicine (Jinan, China). Reverse transcription-quantitative polymerase chain reaction demonstrated that the expression level of miR-766-5p was significantly higher (P
Obesity and cancer risk have a mysterious relationship, with obesity increasing the risk for 13 types of cancer. For some cancers — including pediatric cancers — obesity affects survival rates, which are lower for people who are obese.With an increasing population of overweight and obese children in the United States, researchers and physicians are racing to understand this connection – and what to do about it.Dr.Steven Mittelman, chief of pediatric endocrinology atUCLA Mattel Children ’s Hospital, is among those looking for clues to improve children ’s survival and recovery from cancer. But u...
Conclusions: Enhancing family cohesion and communication within the family can improve the spouses’ HRQOL. Findings regarding sex differences serve as a rationale for gender-based approaches to improving HRQOL in survivorship care in the family context. Implications for Practice: Couple- and/or family-based interventions should be designed to enhance family cohesion and improve family communication skills for effective adjustments within couples and families. Supportive care within the family context can be promoted to address the diverse challenges of survivorship care.
Adjuvant chemotherapy has benefit even if given 6 months or more after resection for stage III colon cancer, a new retrospective study suggests.Reuters Health Information
ConclusionThe high local failure rate and poor oncological outcomes for ypT2-stage rectal cancer patients who undergo CRT followed by LE cannot be justified as an indication for LE. Salvage surgery should be recommended in these patients.
The path to metastatic mouse models of colorectal cancer, Published online: 21 February 2018; doi:10.1038/s41388-018-0155-xThe path to metastatic mouse models of colorectal cancer
A preplanned analysis of ctDNA found that a subpopulation of mCRC patients with acquired anti-EGFR resistance were sensitive to treatment with Sym004.
New research, which was presented at the American Association for the Advancement of Science’s annual conference, has found that moderate drinking is linked to a longer life. Drinking about two glasses of wine or beer a day was linked to an 18% drop in a person’s risk of early death—an even stronger effect than the life-preserving practice of exercise, according to the researchers. The results came from the 90+ Study, a research project out of the University of California Irvine’s Institute for Memory Impairments and Neurological Disorders that examines the habits of people who live to at least 90. ...