Precision Medicine in Metastatic Colorectal Cancer: Relevant Carcinogenic Pathways and Targets —PART 1: Biologic Therapies Targeting the Epidermal Growth Factor Receptor and Vascular Endothelial Growth Factor
Here we review drugs that target the EGFR and VEGF pathways, focusing on patient selection, drug toxicities, and how to choose agents for first-line therapy.
CONCLUSION: Patients treated with verum acupuncture needed less antiemetics and experienced milder nausea than other patients. Our study was small and many analyses lacked statistical power to detect differences; we welcome further sham-controlled efficacy studies and studies regarding the role of non-specific treatment components for experiencing antiemetic effects of acupuncture. PMID: 28917369 [PubMed - in process]
CONCLUSION: A fourth of patients undergoing emetogenic radiotherapy practiced CAM self-care for nausea, mostly by modifying eating or drinking habits. The CAM self-care practicing patients who did not become nauseous practiced self-care more frequent than the nauseous patients did. To make such self-care evidence based, we need studies evaluating its efficacy. PMID: 28917366 [PubMed - in process]
ConclusionsThis study provides key delivery and feasibility data to support the use of IV infusion of enadenotucirev, or therapeutic transgene-bearing derivatives of it, in clinical trials across a range of epithelial tumors, including the ongoing combination study of enadenotucirev with the checkpoint inhibitor nivolumab. It also provides insights into the potential immune-stimulating properties of enadenotucirev.Trial registrationThis MOA study was a phase 1, multicenter, non-randomized, open-label study to investigate the administration of enadenotucirev in a preoperative setting (ClinicalTrials.gov: NCT02053220).
Publication date: December 2017 Source:Phytochemistry, Volume 144 Author(s): Viet Duc Ho, Thi Nhu Hanh Hoang, Quoc Hung Vo, Van Kiem Phan, Tuan Anh Le, Viet Ty Pham, Minh Hien Nguyen, Takeshi Kodama, Takuya Ito, Hiroyuki Morita, Ain Raal, Thi Hoai Nguyen Three cycloartane-type triterpene glycosides (anopanins A–C), together with three known monoacyldigalactosylglycerols gingerglycolipids A–C and (2S)-1-O-palmitoyl-3-O-[α-d-galactopyranosyl-(1→6)-β-d-galactopyranosyl]-sn-glycerol, were isolated from the aerial parts of Anodendron paniculatum collected in Viet Nam. The chemical structures of the ...
This article is protected by copyright. All rights reserved.
Conclusion A subset of HNPCC-associated colorectal cancers in this study clearly showed PD-L1 expression of tumor epithelia and immune cells, therefore, the detection of PD-L1 status is useful.
AbstractAmong the players of the adaptive response of cancer cells able to promote a resistant and aggressive phenotype, carbonic anhydrase IX (CAIX) recently has emerged as one of the most relevant drug targets. Indeed, CAIX targeting has received a lot of interest, and selective inhibitors are currently under clinical trials. Hypoxia has been identified as the master inductor of CAIX, but, to date, very few is known about the influence that another important characteristic of tumor microenvironment, i.e., extracellular acidosis, exerts on CAIX expression and activity. In the last decades, acidic microenvironment has been...
Immunotherapy with modified vaccinia Ankara-5T4 (MVA-5T4, TroVax) may improve survival in patients with metastatic colorectal cancer, researchers report.Reuters Health Information
(National University of Singapore) NUS scientists discovered that a combination of artemisinin, which is a potent anti-malarial drug, and aminolaevulinic acid, which is a photosensitizer, could kill colorectal cancer cells and suppress tumor growth more effectively than administering artemisinin alone. This novel combination therapy could also have fewer side effects.
AbstractPurposeTo evaluate biochemical relapse-free survival (bRFS), overall survival (OS), late rectal and bladder toxicities in a retrospective single institution series, also applying anin-house software for biological dose calculation.Methods258 patients submitted to radiotherapy after prostatectomy were considered. Differences between groups were calculated using the log-rank test and the relevant clinical and therapeutic variables were considered for multivariate analysis. PRODVH is anin-house system able to calculate mean dose-volume histograms (DVHs) of a series of patients, to convert them in biologically effectiv...