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Proton-Beam Therapy in Limited-Stage SCLC Shows Promising Efficacy

Proton-beam therapy was found to be safe for patients with limited-stage small-cell lung cancer in the first prospective registry study of the therapy, with only a small number of high-grade toxicities.
Source: CancerNetwork - Category: Cancer & Oncology Authors: Tags: Lung Cancer News Radiation Oncology Source Type: news

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Publication date: Available online 18 August 2017 Source:Respiratory Medicine Case Reports Author(s): Takayuki Takeda, Hideki Itano, Mayumi Takeuchi, Yurika Nishimi, Masahiko Saitoh, Sorou Takeda The current standard-of-care treatment for patients with limited-stage small-cell lung cancer (SCLC) is concurrent chemoradiotherapy for local and systemic control. However, standard-of-care treatment strategies have not been established for those with limited-stage SCLC who have a history of thoracic radiotherapy due to concerns with complications associated with radiation overdose. A 37-year-old male developed an aspergilloma i...
Source: Respiratory Medicine Case Reports - Category: Respiratory Medicine Source Type: research
AbstractBackgroundThe current study tried to validate the prognostic significance of the 8th American Joint Committee on Cancer (AJCC) staging system among small cell lung cancer (SCLC) patients recorded within the surveillance, epidemiology, and end results (SEER) database.Patients and methodsSEER database (2004 –2014) has been queried through SEER*Stat program, and both AJCC 7th and 8th edition stages were constructed. Cancer-specific and overall survival analyses according to both editions were performed through Kaplan–Meier analysis. The cause-specific Cox regression hazard for both AJCC editions (ad justed...
Source: Clinical and Translational Oncology - Category: Cancer & Oncology Source Type: research
Authors: Bromis K, Gkiatis K, Karanasiou I, Matsopoulos G, Karavasilis E, Papathanasiou M, Efstathopoulos E, Kelekis N, Kouloulias V Abstract Previous studies in small-cell lung cancer (SCLC) patients have mainly focused on exploring neurocognitive deficits associated with prophylactic cranial irradiation (PCI). Little is known about functional brain alterations that might occur due to chemotherapy treatment in this population before PCI is administered. For this reason, we used resting-state functional Magnetic Resonance Imaging (fMRI) to examine potential functional connectivity disruptions in brain networks, inc...
Source: Computational and Mathematical Methods in Medicine - Category: Statistics Tags: Comput Math Methods Med Source Type: research
ConclusionsMetabolic and volumetric PET parameters obtained from pre- and post-treatment FDG PET/CT examinations in patients with SCLC have significant prognostic information.
Source: Nuclear Medicine and Molecular Imaging - Category: Nuclear Medicine Source Type: research
We report a case of 70 year old male who was found to have hyponatremia secondary to SIADH. Radiological tests revealed right hilar lung mass with mediastinal adenopathy. Bronchoscopic biopsy revealed non-small cell lung cancer of type squamous cell. Magnetic resonance imaging (MRI) of brain showed metastatic lesions, thereby confirming diagnosis of metastatic lung cancer. Paraneoplastic syndromes occur in 10% of lung cancer cases and they represent a group of disorders related to secretion of functional polypeptides or hormones from tumor cells. SIADH is more commonly described in conjunction with small cell lung cancer b...
Source: Respiratory Medicine Case Reports - Category: Respiratory Medicine Source Type: research
Proton-beam radiotherapy is safe and appears to be effective in treating some cases of small cell lung cancer (SCLC), an aggressive cancer that accounts for about 10 to 15 percent of all lung cancers, according to a new study published online in the journal Cancer.
Source: University of Maryland School of Medicine News Headlines - Category: Universities & Medical Training Source Type: news
To the Editor: With interest we read the article by Redmond et  al (1) reporting on a prospective study of hippocampal-sparing prophylactic cranial irradiation (HS-PCI) in limited stage small cell lung cancer (SCLC). Within this trial, 20 patients with limited-stage SCLC showing a complete response to chemoradiation therapy and no brain metastases received HS- PCI up to 25 Gy in 10 fractions. At baseline and at 6 and 12 months, magnetic resonance imaging and a battery of neuropsychological tests were performed.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Comments Source Type: research
In this  edition of Oncology Scan, we review recent literature that raises new questions on the topic of prophylactic cranial irradiation (PCI) for small cell lung cancer. Prophylactic cranial irradiation has been considered a standard component of treatment for both limited-stage (LS) and extensive-stage (ES) small cell lung cancer (SCLC) on the basis of high-level evidence demonstrating survival benefits. In 1999, a large meta-analysis pooled individual patient data from 987 LS-SCLC patients in complete remission treated on 7 trials conducted between 1977 and 1994 with a randomization between PCI a nd observation (1).
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Feature Source Type: research
Condition:   SCLC Intervention:   Sponsor:   Fujian Cancer Hospital Not yet recruiting - verified July 2017
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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