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By the Editors Take a look at today's offering from NEJM Group:NEJM Catalyst: Expert …
Source: Physician's First Watch current issue - Category: Primary Care Source Type: news

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Authors: Carrion AF, Martin P Abstract Introduction Glecaprevir/pibrentasvir is a fixed-dose combination regimen of a new generation NS3/4A inhibitor and an NS5A inhibitor with potent antiviral activity against all hepatitis C virus (HCV) genotypes. This regimen offers a shorter course of therapy (8 weeks) for selected patients regardless of genotype and has demonstrated high virological efficacy for retreatment of individuals who previously failed an NS5A containing regimen. Glecaprevir and pibrentasvir are minimally excreted by the kidneys; thus this regimen can safely be used in individuals with severe chronic k...
Source: Expert Opinion on Pharmacotherapy - Category: Drugs & Pharmacology Tags: Expert Opin Pharmacother Source Type: research
This study seeks to characterize the structure-activity relationship between D3T and CDDO-Im in mouse liver tissue. To this end we treated Wt and Nrf2-null mice with 300 umol/kg bw D3T and 3, 10, and 30 umol/kg bw CDDO-Im every other day for 5 days and evaulated global gene expression changes as a product of both treamtent and genotype using Affymetrix microarray.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Mus musculus Source Type: research
Authors: Wang H, Li Z, Guo X, Chen Y, Chen S, Tian Y, Sun Y Abstract BACKGROUND: Despite current interest in the unfavorable impact of nontraditional lipid profiles on cardiovascular disease, information regarding its relations to reduced glomerular filtration rate (GFR) in H-type hypertension population has not been systemically elucidated. METHODS: Analyses were based upon a cross-sectional study of 3259 participants with H-type hypertension who underwent assessment of biochemical, anthropometric, and blood pressure values. Reduced GFR was considered if meeting estimated GFR
Source: Annals of Medicine - Category: Internal Medicine Tags: Ann Med Source Type: research
We examined the association of pro-ENK with eGFR and UAE as a markers of CKD. METHODS: We included 4,375 subjects of the Prevention of Renal and Vascular End-Stage Disease (PREVEND) study. CKDeGFR was defined as development of eGFR 30 mg/24h. RESULTS: Baseline median pro-ENK was 52.2 (IQR: 44.9-60.5) pmol/L. After a median follow-up of 8.4 (IQR: 7.9-8.9) years, 183 subjects developed CKDeGFR and 371 developed CKDUAE. The association of pro-ENK with CKDeGFR was modified by sex (Pinteraction
Source: Biomarkers - Category: Research Tags: Biomarkers Source Type: research
ConclusionLow levels of parathyroid hormone before transplantation were associated with increased risk of post-transplant vascular events both in patients with and without pre-transplant parathyroidectomy. Any conclusions on causal or direct effect of PTH on outcome cannot be drawn from this observational study.
Source: Clinical and Experimental Nephrology - Category: Urology & Nephrology Source Type: research
FRIDAY, Feb. 23, 2018 -- Chronic kidney disease may affect brain function in children and teens, especially those on dialysis, researchers say. Results of their study review suggest academic assistance may be needed in specific areas, including...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
Conclusions In this case-control, survey-based study, the prevalence of nephrolithiasis was 2 times higher in patients with CLD.
Source: Journal of Clinical and Experimental Hepatology - Category: Gastroenterology Source Type: research
AbstractMany cardiovascular diseases present renin –angiotensin–aldosterone system (RAAS) hyperactivity as an important pathophysiological mechanism to be target in the therapeutic approaches. Moreover, arterial stiffness is currently considered as a new independent risk factor for cardiovascular disease in different clinical conditions, includi ng hypertension and chronic kidney disease. In fact, excessive stimulation of angiotensin type 1 (AT1) receptors, as well as mineralocorticoid receptors, results in cellular growth, oxidative stress and vascular inflammation, which may lead to arterial stiffness and acc...
Source: High Blood Pressure and Cardiovascular Prevention - Category: Cardiology Source Type: research
There is a large and growing burden of diabetes globally. In 2013, 382 million people had diabetes and this number has been projected to increase to 592 million by 2035 [1]. With increasing life expectancy and prevalence of type 2 diabetes, complications and deaths attributable to diabetes will also increase, especially if there is no concomitant improvement in the health system for its early management [1]. Chronic kidney disease (CKD) is a common complication in people with type 2 diabetes [2] and may in some cases progress to end-stage renal disease, which requires dialysis and/or kidney transplant which are associated ...
Source: Primary Care Diabetes - Category: Primary Care Authors: Tags: Original research Source Type: research
Source: International Journal of Nursing Studies - Category: Nursing Authors: Tags: Cochrane Nursing Care Field (CNCF) – Cochrane Review Summary Source Type: research
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