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By the Editors Take a look at today's offering from NEJM Group:NEJM Catalyst: Expert …
Source: Physician's First Watch current issue - Category: Primary Care Source Type: news

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Conclusion RIPC does not result in significant reduction of CIN. However RIPC helps in the prevention of post procedural worsening in eGFR and serum creatinine even up to 6 weeks.
Source: Indian Heart Journal - Category: Cardiology Source Type: research
Source: Journal of the American College of Cardiology: Cardiovascular Interventions - Category: Cardiology Authors: Tags: To the Editor Source Type: research
Source: Journal of the American College of Cardiology: Cardiovascular Interventions - Category: Cardiology Authors: Tags: To the Editor Source Type: research
ConclusionAntioxidant treatment with melatonin was shown to ameliorate intrarenal RAS activation and renal injury in a 5/6 Nx rat model.
Source: Clinical and Experimental Nephrology - Category: Urology & Nephrology Source Type: research
AbstractBackgroundThe accumulation ofp-cresol, a metabolic product of aromatic amino acids generated by intestinal microbiome, increases the cardiovascular risk in chronic kidney disease (CKD) patients. Therefore, therapeutic strategies to reduce plasmap-cresol levels are highly demanded. It has been reported that the phosphate binder sevelamer (SEV) sequestersp-cresol in vitro, while in vivo studies on dialysis patients showed controversial results. Aim of our study was to evaluate the effect of SEV onp-cresol levels in non-dialysis CKD patients.MethodsThis was a single-blind, randomized placebo-controlled trial (Registra...
Source: Clinical and Experimental Nephrology - Category: Urology & Nephrology Source Type: research
AbstractIntroductionErtugliflozin is a sodium-glucose cotransporter 2 inhibitor in development for type 2 diabetes mellitus (T2DM). The safety and efficacy of ertugliflozin were evaluated over 52  weeks in patients with chronic kidney disease (CKD).MethodsIn this double-blind randomized study (NCT01986855), patients with glycated hemoglobin (A1C) 7.0 –10.5% and stage 3 CKD [estimated glomerular filtration rate (eGFR) ≥ 30 to 
Source: Diabetes Therapy - Category: Endocrinology Source Type: research
Authors: Monzon T, Valga F, Mahtani V PMID: 29150127 [PubMed - as supplied by publisher]
Source: Medicina Clinica - Category: General Medicine Tags: Med Clin (Barc) Source Type: research
Abstract BackgroundThe Systolic Blood Pressure Intervention Trial (SPRINT; ClinicalTrials.gov, NCT01206062) reported reduced cardiovascular events by intensive blood pressure (BP) control amongst hypertensive patients without diabetes. However, the risk–benefit profile of intensive BP control may differ across estimated glomerular filtration rate (eGFR) levels. MethodsThis is a post hoc analysis of the SPRINT. Nondiabetic hypertensive adults (n = 9361) with eGFR>20 mL per min per 1.73 m2 were enrolled from 102 US facilities between November 2010 and March 2013 and were followed up until August ...
Source: Journal of Internal Medicine - Category: Internal Medicine Authors: Tags: Original Article Source Type: research
CONCLUSIONS: Distal forearm arteries in diabetics may be severely atherosclerotic. Forearm loop arteriovenous fistula can be considered as the primary access for cases decided as inconvenient for fistula creation due to severe occlusive atherosclerotic disease of the forearm arteries; in order to preserve upper arm veins for future access procedures. PMID: 29148006 [PubMed - as supplied by publisher]
Source: The Journal of Vascular Access - Category: Surgery Tags: J Vasc Access Source Type: research
Objective: We aimed to determine the factors contributing toward diffusely increased renal uptake on bone scintigraphy using technetium-99m (Tc-99m) diphosphono-propanedicarboxylic acid (DPD) in patients with end-stage renal disease. Patients and methods: One-hundred and forty-three bone scintigraphies, performed between June 2007 and July 2013, in 135 patients with chronic kidney disease were analyzed retrospectively, including 22 bone scintigraphies (15 patients; eight women; seven men) with glomerular filtration rates less than 15 ml/min/1.73 m2. Patients with nephrocalcinosis were excluded. The clinical ...
Source: Nuclear Medicine Communications - Category: Nuclear Medicine Tags: Original Articles Source Type: research
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