Gibberellin ‐regulated protein in Japanese apricot is an allergen cross‐reactive to Pru p 7

Conclusions and Clinical RelevanceThese results indicated that GRP might be a causative allergen of JA allergy, whose onset frequently requires a cofactor, such as exercise, and might be cross‐reactive between JAs and peaches. We identified gibberellin‐regulated protein (GRP, also known as peamaclein) as the first allergen in Japanese apricot allergy, whose onset frequently requires a cofactor, such as exercise. In addition, ELISA inhibition assays indicated that GRP might be cross‐reactive between Japanese apricots and peaches. Cross‐reactivity between Japanese apricot GRP and peach GRP, Pru p 7, might be explained by high similarity (100%) of their amino acid sequences, and support the co‐existence of allergy to both Japanese apricots and peaches in all seven patients with Japanese apricot allergy.
Source: Immunity, Inflammation and Disease - Category: Allergy & Immunology Authors: Tags: Original Research Source Type: research