Hantaviruses Induce Antiviral and Pro-inflammatory Innate Immune Responses in Astrocytic Cells and the Brain

Viral Immunology , Vol. 0, No. 0.
Source: Viral Immunology - Category: Allergy & Immunology Tags: article Source Type: research

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rta Roberta Loddo Orthohantaviruses, previously known as hantaviruses (family Hantaviridae, order Bunyavirales), are emerging zoonoses hosted by different rodent and insectivore species. Orthohantaviruses are transmitted by aerosolized excreta (urine, saliva and feces) of their reservoir hosts. When transmitted to humans, they cause hemorrhagic fever with renal syndrome (HFRS) in Asia and Europe and hantavirus (cardio) pulmonary syndrome (HPS) in the Americas. Clinical studies have shown that early treatments of HFRS patients with ribavirin (RBV) improve prognosis. Nevertheless, there is the need for urgent developme...
Source: Viruses - Category: Virology Authors: Tags: Communication Source Type: research
Vincent and Rich travel to Galveston National Laboratory to speak with Jim LeDuc, Tom Ksiazek, and Bob Tesch about their long careers as virus hunters. Click arrow to play Download TWiV 583 (51 MB .mp3, 84 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Show notes at microbe.tv/twiv
Source: virology blog - Category: Virology Authors: Tags: This Week in Virology arbovirus BSL4 laboratory ebolavirus galveston national laboratory hantavirus Nipah virus select agent Texas Medical Branch viral virus hunters viruses Source Type: blogs
Hantavirus infection is worldwide epidemic and can cause life-threatening consequences. With more and more cases reported in countries with atypical morbidity, it is necessarily urgent to know some atypical sy...
Source: BMC Infectious Diseases - Category: Infectious Diseases Authors: Tags: Case report Source Type: research
S. Chand et al.
Source: Emerging Infectious Diseases Journal - Category: Infectious Diseases Source Type: research
by Bruno Tardelli Diniz Nunes, Maria Helena Rodrigues de Mendon ça, Darlene de Brito Simith, Adriana Freitas Moraes, Carla Conceição Cardoso, Ivy Tsuya Essashika Prazeres, Ana Alice de Aquino, Alessandra da Conceição Miranda Santos, Alice Louize Nunes Queiroz, Daniela Sueli Guerreiro Rodrigues, Regis Bruni Andriolo, Elizabeth Salbé Travassos da Rosa, Livia Carício Martins, Pedro Fernando da Costa Vasconcelos, Daniele Barbosa de Almeida Medeiros Hantavirus Pulmonary Syndrome is an, often fatal, emerging zoonotic disease in the Americas caused by hantaviruses (family:Hantavir...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
We present HCPS in a child from the Pantanal Biome and a review of all reported pediatric cases in Mato Grosso State, an endemic area for HCPS in Brazil. The investigation used the Information System for Notifiable Diseases database (SINAN). A 12-year-old boy was hospitalized with fever and respiratory failure and hantavirus IgM and IgG antibodies were detected by ELISA in serum samples. During the period of 1999 to 2016, 32 HCPS pediatric cases confirmed by serology were reported to SINAN with a mortality rate of 34.4%. The possibility of hantavirus infection in children with acute febrile illness associated with respirat...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - Category: Tropical Medicine Authors: Tags: Rev Inst Med Trop Sao Paulo Source Type: research
CONCLUSIONS: Arenavirus and hantavirus circulate in in digenous populations from the Colombian Caribbean region, and the results indicate that the indigenous populations are exposed to these zoonotic agents, with unknown consequences on their health, despite low seroprevalence.
Source: Revista da Sociedade Brasileira de Medicina Tropical - Category: Tropical Medicine Source Type: research
Conclusion/SignificanceIn silico analysis revealed nine potential immunogenic linear B-cell epitopes from SHNP; among them, SHNP(G72-D110) and SHNP(P251-D264) showed a high degree of sequence conservation among HFRS-related orthohantavirus and were experimentally validated against rSHNP-IMS and negatively validated against rJHNP-IMS. Taken together, we identified and validated two potential antigenic B-cell epitopes on SHNP, which were conserved among HFRS-associated orthohantavirus and could be applied to the development of novel immunodiagnostic tools for orthohantavirus surveillance.
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
Vincent speaks with members of Prometheus, a team of academic and industrial scientists assembled to develop antibody-based therapeutics against infections caused by tick-borne Crimean-Congo hemorrhagic fever virus and rodent-borne hantaviruses, for which no approved vaccines or specific drugs are available. Click arrow to play Download TWiV 578 (55 MB .mp3, 91 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become […]
Source: virology blog - Category: Virology Authors: Tags: This Week in Virology Crimean-Congo hemorrhagic fever virus hantavirus monoclonal antibody therapy rodent-borne virus tick-borne virus U19 grant viral viruses Source Type: blogs
Kumiko Yoshimatsu Dear Drs. W. Katherine Yih, Martin Kulldorff, Jessica H. Leibler, David J. Friedman, and Daniel R. Brooks [...]
Source: Viruses - Category: Virology Authors: Tags: Reply Source Type: research
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