Volatile organic compounds in gastrointestinal stromal tumour tissue originating from patient-derived xenografts
Gastrointestinal stromal tumours (GISTs) are the most common mesenchymal neoplasms of the
gastrointestinal tract and localize mainly in the stomach or small intestine. The metabolomic
signatures of GISTs driven by different KIT gene mutations remain undiscovered and unexplored. The
main aim of this pilot study was to determine and compare metabolomic profiles in GIST xenograft
models with different genetic backgrounds. Metabolomic profiling using gas chromatography coupled
with mass spectrometry followed by univariate and multivariate statistical analyses was applied to
select metabolites that differentiated the GIST models studied. The significant differences observed
in the metabolites were mainly derived from glycolysis, the citric acid cycle and glutamine and
lipid metabolism. The obtained results may suggest variable metabolomic signatures of tumours,
possibly related to the different underlying, specific KIT gene mutations and with potential
implications for ...
Source: Journal of Breath Research - Category: Respiratory Medicine Authors: Renata Wawrzyniak, Agnieszka Wo źniak, YeMarshet K Gebreyohannes, Bartosz Dykcik, Patrick Schöffski and Michał J Markuszewski Source Type: research