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Adverse Drug Event Causality Analysis (ADECA): a process for evaluating evidence and assigning drugs to risk categories for sudden death - Woosley RL, Romero K, Heise CW, Gallo T, Tate J, Woosley RD, Ward S.

Growing evidence indicates that many drugs have the ability to cause a potentially lethal cardiac arrhythmia, torsades de pointes (TdP). This necessitates the development of a compilation of drugs that have this potential toxicity. Such a list is helpful i...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

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There is mounting evidence that besides increasing risk of cirrhosis, end stage liver disease and hepatocellular carcinoma, non alcoholic fatty liver disease (NAFLD) also affects risk of disease in organs beyond the liver[1]. For example, NAFLD is an independent risk factor for cardiovascular disease[2], type 2 diabetes[3] and chronic kidney disease[4], and NAFLD also increases risk of cardiac arrhythmias and aortic valve disease [1]. However, whether NAFLD is a risk factor for impaired myocardial function is uncertain.In a study of 308 asymptomatic subjects recruited from attendees at a Health Promotion Centre in a Univer...
Source: Journal of Hepatology - Category: Gastroenterology Authors: Source Type: research
We tested for pleiotropy in European ancestry subjects (N>90K) via GWAS of systolic and diastolic blood pressure (BP), mean arterial pressure, and pulse pressure, using gene (G)-alcohol consumption (E) interactions. The approach was a correlated meta-analysis (PMCID-PMC3773990) that combined simultaneously the 4 BP traits genome-wide GxE interactions summary meta-P values. This approach adjusts for correlations among single traits at the genomic level. A variant was considered pleiotropic when the overall correlated meta-analysis yielded P≤5E-08 and GxE meta-P≤E-04 for at least two single traits. The novel pleiotr...
Source: Hypertension - Category: Cardiology Authors: Tags: Poster Abstract Presentations Source Type: research
CONCLUSION: 1) health care providers should educate youth and their parents about the risks of caffeinated drinks; 2) emergency department clinicians should consider asking patients about ED and traditional caffeine usage and substance use when assessing patient symptoms; 3) policy makers should  increase their attention on introducing regulatory policies on television food advertising to which youth are exposed;  4) failure to comply with standards for efficacious product labelling, and absence of broader education regarding guidelines, need to be addressed and 5) further studies must be done to improve our unde...
Source: Acta Bio-Medica : Atenei Parmensis - Category: General Medicine Authors: Tags: Acta Biomed Source Type: research
Source: Digestive and Liver Disease - Category: Gastroenterology Authors: Tags: Correspondence Source Type: research
ConclusionsThere was a high prevalence of vitamin D deficiency in the elderly, and the evidence shows a strong association between vitamin D deficiency and increased risk of heart failure in this population.
Source: ESC Heart Failure - Category: Cardiology Authors: Tags: Original Research Article Source Type: research
ConclusionIndividuals who worked long hours were more likely to develop atrial fibrillation than those working standard hours.
Source: European Heart Journal - Category: Cardiology Source Type: research
Authors: Chu T, Azevedo K, Ernst AA, Sarangarm D, Weiss SJ Abstract OBJECTIVES: Patients with an alcohol use disorder experiencing acute intoxication or withdrawal may be at risk for electrocardiograph (ECG) abnormalities, including prolongation of repolarization (long QTc [corrected QT]) that may contribute to arrhythmias and may be associated with a threefold increase in the likelihood of sudden cardiac events. Patients with acute coronary syndrome may have prolonged QTc as well. To our knowledge, no previous studies have compared the QTc of ACS with acute ethanol (EtOH) withdrawal syndromes in the emergency depa...
Source: Southern Medical Journal - Category: General Medicine Tags: South Med J Source Type: research
Conclusion and Recommendations More intervention-based clinical trials are needed to provide a strong alternative candidate therapy for management of opiate use disorder. Buprenorphine, although a promising candidate, should be researched more regarding treatment retention and patient satisfaction before any conclusions can be made regarding its standard use for opiate substitution maintenance treatment of pregnant patients with opiate use disorder. Heroin-assisted treatment still cannot be considered in opiate addicts refractory to MMT; more data should be collected regarding efficacy in larger participant populations un...
Source: Innovations in Clinical Neuroscience - Category: Neuroscience Authors: Tags: Current Issue General Review buphernorphin heroin methadone opiate opiate addiction treatment withdrawal Source Type: research
Abstract Atrial fibrillation (AF) is a common cardiac arrhythmia, and pathological burden can be influenced by environmental factors. The rural environment may influence the burden of AF, although no systematic review studies have been conducted to address this issue. We performed a systematic review of AF screening studies conducted in rural global populations to determine the burden, risk factors, and screening methods surrounding AF in these settings. Out of the 1792 articles gathered from a keyword search of medical databases and reference lists, 18 publications from 11 countries were included in our analysis....
Source: Baylor University Medical Center Proceedings - Category: Universities & Medical Training Authors: Tags: Proc (Bayl Univ Med Cent) Source Type: research
This editorial refers to ‘Alcohol consumption, sinus tachycardia, and cardiac arrhythmias at the Munich Octoberfest: results from the Munich Beer Related Electrocardiogram Workup Study (MunichBREW)’††, by S. Brunneret al., on page2100.
Source: European Heart Journal - Category: Cardiology Source Type: research
More News: Alcoholism | Arrhythmia | Cardiac Arrhythmia | Toxicology