Adverse Drug Event Causality Analysis (ADECA): a process for evaluating evidence and assigning drugs to risk categories for sudden death - Woosley RL, Romero K, Heise CW, Gallo T, Tate J, Woosley RD, Ward S.

Growing evidence indicates that many drugs have the ability to cause a potentially lethal cardiac arrhythmia, torsades de pointes (TdP). This necessitates the development of a compilation of drugs that have this potential toxicity. Such a list is helpful i...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

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Conclusion: The most common ECG changes associated with acute alcohol intoxication are (in decreasing order of frequency) P-wave and QTc prolongation, followed by T-wave abnormalities and QRS complex prolongation. Mostly, these changes are completely reversible. PMID: 29541259 [PubMed]
Source: Open Cardiovascular Medicine Journal - Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research
In this paper, we report the autopsy findings of a 42-year-old White male who was found deceased at his home by his brother in the early morning hours with a history of excessive alcohol consumption 1 day before his death. A medical record review revealed chronic alcohol use with alcohol dependence syndrome, hypertension, and cardiac arrhythmias by electrocardiogram 2 years prior. External examination revealed only a single bruise on the forehead. Internal examination revealed changes associated with chronic alcohol abuse and mild atherosclerosis. The lack of a cause of death at autopsy resulted in a dissection of the card...
Source: The American Journal of Forensic Medicine and Pathology - Category: Forensic Medicine Tags: Case Reports Source Type: research
Cyclizine is sold in Denmark as an over-the-counter drug and affects not only histaminergic but also muscarinergic, serotonergic and α-adrenergic receptors, with side effects such as respiratory depression and cardiac arrhythmias, leading to fatalities. D...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
There is mounting evidence that besides increasing the risk of cirrhosis, end-stage liver disease and hepatocellular carcinoma, non-alcoholic fatty liver disease (NAFLD) also affects risk of disease in organs beyond the liver.1 For example, NAFLD is an independent risk factor for cardiovascular disease (CVD),2 type 2 diabetes3 and chronic kidney disease,4 and NAFLD also increases risk of cardiac arrhythmias and aortic valve disease.1 However, whether NAFLD is a risk factor for impaired myocardial function is uncertain.
Source: Journal of Hepatology - Category: Gastroenterology Authors: Tags: Editorial Source Type: research
There is mounting evidence that besides increasing risk of cirrhosis, end stage liver disease and hepatocellular carcinoma, non alcoholic fatty liver disease (NAFLD) also affects risk of disease in organs beyond the liver[1]. For example, NAFLD is an independent risk factor for cardiovascular disease[2], type 2 diabetes[3] and chronic kidney disease[4], and NAFLD also increases risk of cardiac arrhythmias and aortic valve disease [1]. However, whether NAFLD is a risk factor for impaired myocardial function is uncertain.In a study of 308 asymptomatic subjects recruited from attendees at a Health Promotion Centre in a Univer...
Source: Journal of Hepatology - Category: Gastroenterology Authors: Source Type: research
We tested for pleiotropy in European ancestry subjects (N>90K) via GWAS of systolic and diastolic blood pressure (BP), mean arterial pressure, and pulse pressure, using gene (G)-alcohol consumption (E) interactions. The approach was a correlated meta-analysis (PMCID-PMC3773990) that combined simultaneously the 4 BP traits genome-wide GxE interactions summary meta-P values. This approach adjusts for correlations among single traits at the genomic level. A variant was considered pleiotropic when the overall correlated meta-analysis yielded P≤5E-08 and GxE meta-P≤E-04 for at least two single traits. The novel pleiotr...
Source: Hypertension - Category: Cardiology Authors: Tags: Poster Abstract Presentations Source Type: research
CONCLUSION: 1) health care providers should educate youth and their parents about the risks of caffeinated drinks; 2) emergency department clinicians should consider asking patients about ED and traditional caffeine usage and substance use when assessing patient symptoms; 3) policy makers should  increase their attention on introducing regulatory policies on television food advertising to which youth are exposed;  4) failure to comply with standards for efficacious product labelling, and absence of broader education regarding guidelines, need to be addressed and 5) further studies must be done to improve our unde...
Source: Acta Bio-Medica : Atenei Parmensis - Category: General Medicine Authors: Tags: Acta Biomed Source Type: research
Source: Digestive and Liver Disease - Category: Gastroenterology Authors: Tags: Correspondence Source Type: research
ConclusionsThere was a high prevalence of vitamin D deficiency in the elderly, and the evidence shows a strong association between vitamin D deficiency and increased risk of heart failure in this population.
Source: ESC Heart Failure - Category: Cardiology Authors: Tags: Original Research Article Source Type: research
ConclusionIndividuals who worked long hours were more likely to develop atrial fibrillation than those working standard hours.
Source: European Heart Journal - Category: Cardiology Source Type: research
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