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Effect of Munghurt Lactobacillus acidophilus from Green Beans to Blood Glucose Levels in Alloxan-induced Diabetic Rats

The objective of this research was to determine effect of munghurt Lactobacillus acidophilus to blood glucose levels in diabetic rats induced alloxan. Materials and Methods: The samples (n=25) were divided into five groups, negative control (Negative); positive control (Positive); glibenclamide-treated (Glibenclamide); munghurt Lactobacillus acidophilus-treated (Munghurt); glibenclamide and munghurt Lactobacillus acidophilus combination-treated (Glibenclamide+Munghurt). Diabetes rat was induced by an intraperitoneal injection of alloxan. Munghurt Lactobacillus acidophilus was orally administered to normal and diabetic rats for a period of 4 weeks. Blood glucose level was observed on 0 and 28 days. Data were statistically analyzed using Kruskall Wallis and Mann Whitney test and further by one way ANOVA and Tukey post hoc test. Results: Munghurt Lactobacillus acidophilus decreased blood glucose level significantly on 28 days (p = 0.001) with blood glucose level mean of 87.32±5.15 mg dL–1 (negative), 233±17.323 mg dL–1 (positive), 117.36±8.153 mg dL–1 (munghurt), 105.46±3,756 mg dL–1 (glibenclamide) and 105±4.617 mg dL–1 (munghurt+glibenclamide) respectively. Munghurt Lactobacillus acidophilus combined with glibenclamide had best results at lowering blood glucose in diabetic rats (p
Source: Research Journal of Medicinal Plant - Category: Complementary Medicine Source Type: research

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