Effect of Munghurt Lactobacillus acidophilus from Green Beans to Blood Glucose Levels in Alloxan-induced Diabetic Rats

The objective of this research was to determine effect of munghurt Lactobacillus acidophilus to blood glucose levels in diabetic rats induced alloxan. Materials and Methods: The samples (n=25) were divided into five groups, negative control (Negative); positive control (Positive); glibenclamide-treated (Glibenclamide); munghurt Lactobacillus acidophilus-treated (Munghurt); glibenclamide and munghurt Lactobacillus acidophilus combination-treated (Glibenclamide+Munghurt). Diabetes rat was induced by an intraperitoneal injection of alloxan. Munghurt Lactobacillus acidophilus was orally administered to normal and diabetic rats for a period of 4 weeks. Blood glucose level was observed on 0 and 28 days. Data were statistically analyzed using Kruskall Wallis and Mann Whitney test and further by one way ANOVA and Tukey post hoc test. Results: Munghurt Lactobacillus acidophilus decreased blood glucose level significantly on 28 days (p = 0.001) with blood glucose level mean of 87.32±5.15 mg dL–1 (negative), 233±17.323 mg dL–1 (positive), 117.36±8.153 mg dL–1 (munghurt), 105.46±3,756 mg dL–1 (glibenclamide) and 105±4.617 mg dL–1 (munghurt+glibenclamide) respectively. Munghurt Lactobacillus acidophilus combined with glibenclamide had best results at lowering blood glucose in diabetic rats (p
Source: Research Journal of Medicinal Plant - Category: Complementary Medicine Source Type: research

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Publication date: 15 April 2019Source: Sensors and Actuators B: Chemical, Volume 285Author(s): Yu-Wen Chen, Arun Prakash Periasamy, Chien-Fu Chen, Huan-Tsung ChangAbstractThe monitoring of glucose levels in blood is extremely important for the effective control of diabetes. Nanomaterial-based approaches for the quantification of glucose typically require two steps: material preparation and the actual glucose measurement. Herein, we report a single-step method that combines these functions via the in situ growth of Cu2O/Ag nanoparticles (NPs). Mechanistically, we use glucose itself to reduce Cu2+ and Ag+ ions that are stabi...
Source: Sensors and Actuators B: Chemical - Category: Chemistry Source Type: research
DIABETES type 2 symptoms include unexplained weight loss, passing more urine than normal, and feeling very tired. But you could also be at risk of high blood sugar if you have this painful sign hanging from your skin.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
An association of altered activity of transient receptor potential cation channel C6 (TRPC6) with the development of various diabetic complications was previously reported. In this issue, Wang et  al. tested the contribution of TRPC6 in type 1 diabetes setting by breeding Akita mice with TRPC6 knockout mice. The authors revealed that the knockout of TRPC6 decreased proteinuria and attenuated tubule injury but promoted mesangial expansion in Akita mice. Therefore, TRPC6 has both beneficial a nd detrimental effects on glomeruli function.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Commentary Source Type: research
Gain-of-function mutations in TRPC6 cause familial focal segmental glomerulosclerosis, and TRPC6 is upregulated in glomerular diseases including diabetic kidney disease. We studied the effect of systemic TRPC6 knockout in the Akita model of type 1 diabetes. Knockout of TRPC6 inhibited albuminuria in Akita mice at 12 and 16 weeks of age, but this difference disappeared by 20 weeks. Knockout of TRPC6 also reduced tubular injury in Akita mice; however, mesangial expansion was significantly increased.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Basic Research Source Type: research
A 52-year-old man with diabetes mellitus, congestive heart failure, morbid obesity (body mass index: 37), and chronic kidney disease started peritoneal dialysis using a surgically inserted catheter (midline incision). Catheter dysfunction necessitated surgical repositioning. During the operation, a cavity localized in the subcutaneous fat of the abdominal wall was discovered, with connection to the peritoneum space and the entire catheter within the cavity. The malfunctioning catheter was replaced through the same insertion site without an attempt to fix the cavity.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Nephrology Image Source Type: research
Sugar could become an effective replacement for metal in contrast agents in magnetic resonance tomography analyses, according to researchers from John Hopkins University and Lund University in Sweden.There has been heated debate over the safety of certain contrast agents, and the Food and Drug Administration has  warnedthat gadolinium-based contrast agents (GBCAs) can linger in the brain for months or years after the patient ’s procedure. Using alternatives like sugar could potentially diminish the risk of adverse side effects associated with GBCAs. Studies using animals demonstrated that D-glucose could be a po...
Source: radRounds - Category: Radiology Authors: Source Type: blogs
ConclusionsIn China, active case finding (ACF) could be implemented among elderly people aged 65 and above with underweight, diabetes, close contact history and previous TB history as a priority, which will get significant yields and be cost-effective.
Source: Infectious Diseases of Poverty - Category: Infectious Diseases Source Type: research
AbstractIntroductionThe data on the role of OAGB in super obese patients and its direct comparison with LSG in super obese patients is scarce.ObjectivesTo compare weight loss, impact on comorbidities and nutritional parameters between LSG and OAGB in super obese patients.MethodsProspectively collected data of 75 matched patients with BMI  >  50, who underwent either laparoscopic sleeve gastrectomy (LSG) or one anastomosis gastric bypass (OAGB), was analyzed retrospectively. Percentage excess weight loss at 1 year and impact on comorbidities were compared in both the groups.ResultsBoth the groups were ...
Source: Obesity Surgery - Category: Surgery Source Type: research
The advisory committee voted 8-8 on approving the drug, to be called Zynquista, which would be the first oral medication for people with Type 1 diabetes.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Food and Drug Administration Lexicon Pharmaceuticals Inc Sanofi SA Drugs (Pharmaceuticals) Diabetes Source Type: news
Conclusions: MetS predicts the risk of T2DM. The quantitative MetS-based prediction model for T2DM risk may improve preventive strategies for T2DM and present considerable public health benefits for the people in mainland China. PMID: 30647739 [PubMed]
Source: International Journal of Endocrinology - Category: Endocrinology Tags: Int J Endocrinol Source Type: research
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