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Newsdesk Incarceration and infection: drug policy in the USA

The USA is in the midst of an opiate addiction crisis. Resurrecting the war on drugs will only serve to harm public health and risks spreading infections. Talha Burki reports.
Source: The Lancet Infectious Diseases - Category: Infectious Diseases Authors: Tags: Newsdesk Source Type: research

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Authors: Phillips PK, Caldis MW, Hristov AD, Lee AS, Lucey MR Abstract The manufacture and consumption of alcohol are ubiquitous and as old as time. Alcohol use disorder (AUD) is defined as a problematic pattern of alcohol use leading to clinically significant impairment. The physical injuries that result from excessive alcohol consumption are varied including end-organ damage to liver (alcohol-associated liver disease or ALD), pancreas, brain and heart, and systemic consequences including several forms of cancer. Liver transplantation (LT) remains the treatment of last resort for life-threatening liver disease. LT...
Source: Minerva Gastroenterologica e Dietologica - Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research
Decimated by addiction, its heritage at risk, the Cherokee Nation is trying to sue pharmacies and distributors. But it may be blocked from doing so.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Cherokee Indians Drugs (Pharmaceuticals) Addiction (Psychology) Suits and Litigation (Civil) AmerisourceBergen Corp CVS Caremark Corporation Cardinal Health Inc Walgreen Co. opioids Source Type: news
(Natural News) In an effort to curb opioid use, the University of Florida Health Shands Hospital implemented the enhanced recovery after surgery (ERAS) protocol in mid-2015. Under this, doctors can no longer impose narcotics on patients with impunity, and must make an effort to find and write prescriptions. Come 2017, and the results can already...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
Has cabin fever struck you yet this winter? Find out ways to beat it, plus the latest on a new scientist-created version of oxytocin, how orange light therapy might help mental illness symptoms, why global teamwork might be helpful for psychological studies, and more in this week’s Psychology Around the Net! How to Beat Cabin Fever When You’re Stuck Inside This Winter: Try a couple — or all — of these ideas for combating cabin fever (or, in some of our cases, the funk that comes along with shorter days and less sunshine). Can Teamwork Solve One Of Psychology’s Biggest Problems? Psychologist ...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: ADHD and ADD Anxiety and Panic Bipolar Health-related Medications Psychology Around the Net Research Schizophrenia Technology amphetamines Attention Deficit Hyperactivity Disorder cabin fever Christopher Chartier Light therapy Source Type: blogs
The opioid crisis has attracted increasing commentary during 2017. A recent study has shown that after surgery, in the USA, one in 16 patients will become a chronic opioid user.1 This number does not differ when comparing minor versus major surgery and largely represents inappropriate use of opioid analgesics triggered by overprescribing. This problem emphasises the need to optimise health-care delivery and to develop new, effective, and non-addictive drugs for the treatment of chronic pain.
Source: Lancet Neurology - Category: Neurology Authors: Tags: 2017 Round-up Source Type: research
Publication date: December 2017 Source:Pharmacology Biochemistry and Behavior, Volume 163 Author(s): Michael C. Salling, Christopher J. Hodge, Kelly E. Psilos, Vallari R. Eastman, Sara P. Faccidomo, Clyde W. Hodge Cue-induced reinstatement of alcohol-seeking is a hallmark behavioral pathology of addiction. Evidence suggests that reinstatement (e.g., relapse), may be regulated by cell signaling systems that underlie neuroplasticity. A variety of plasticity events require activation of calcium calmodulin-dependent protein kinase II (CaMKII) in components of the reward pathway, such as the nucleus accumbens and amygdala. We ...
Source: Pharmacology Biochemistry and Behavior - Category: Biochemistry Source Type: research
In this study, we investigated the roles for other chemokines mediating Meth-induced CPP and the upstream factors upregulating chemokines in mice. We found that CCL7 mRNA level was upregulated in the prefrontal cortex (PFC) after Meth administration (3mg/kg, subcutaneous), and increased CCL7 immunoreactivity was localized to the PFC NeuN-positive neurons. Meth-induced CPP was blocked by the dopamine D1 receptor antagonist SCH 23390 but not by the D2 receptor antagonists raclopride or haloperidol. The D1 receptor agonist SKF 81297 alone elicited CPP, suggesting a critical role of D1 receptor signaling in Meth-induced reward...
Source: Neuroscience Letters - Category: Neuroscience Source Type: research
In conclusion, morphine was capable of inducing changes in the structural plasticity of primary cultured mouse cortical neurons, and Cav-1 played an important role in this process. Inhibition of Cav-1 expression reduced the morphine-induced increase in the neuronal growth markers GAP-43 and MAP-2. Thus, Cav-1 may be a potential molecular target for inhibiting morphine-induced neuroplasticity.
Source: Neuroscience Letters - Category: Neuroscience Source Type: research
Publication date: 5 February 2018 Source:Neuroscience Letters, Volume 665 Author(s): Yanjiong Chen, Cuo Yang, Li Zhu, Jiaqi Li, Fanglin Guan, Teng Chen The role of the D3 dopamine receptor (D3R) and the specific molecular mechanisms underlying the regulation of D3R via the cAMP signaling pathway in methamphetamine (METH) addiction are still unclear. Here, we measured changes in Pde4b and Atf3 in the cAMP signaling pathway of dopaminergic system components, including the nucleus accumbens (NAc), caudate putamen (CPu) and hippocampus (Hip), in D3R knockout mice(D3R-/-) 1h and 24h after METH-induced behavioral sensitization....
Source: Neuroscience Letters - Category: Neuroscience Source Type: research
Conclusion Many of the lifestyle practices such as tobacco use, alcohol consumption and physical inactivity were prevalent amongst elderly. Majority of them were suffering from more than one morbidity, which was found to be associated with their unhealthy lifestyle practices. There is a need to target interventions for inculcating healthy lifestyle practices amongst elderly.
Source: Clinical Epidemiology and Global Health - Category: Epidemiology Source Type: research
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