Intranasal cotinine improves memory, and reduces depressive-like behavior, and GFAP+ cells loss induced by restraint stress in mice.

Intranasal cotinine improves memory, and reduces depressive-like behavior, and GFAP+ cells loss induced by restraint stress in mice. Exp Neurol. 2017 Jun 15;295:211-221 Authors: Perez-Urrutia N, Mendoza C, Alvarez-Ricartes N, Oliveros-Matus P, Echeverria F, Grizzell JA, Barreto GE, Iarkov A, Echeverria V Abstract Posttraumatic stress disorder (PTSD), chronic psychological stress, and major depressive disorder have been found to be associated with a significant decrease in glial fibrillary acidic protein (GFAP) immunoreactivity in the hippocampus of rodents. Cotinine is an alkaloid that prevents memory impairment, depressive-like behavior and synaptic loss when co-administered during restraint stress, a model of PTSD and stress-induced depression, in mice. Here, we investigated the effects of post-treatment with intranasal cotinine on depressive- and anxiety-like behaviors, visual recognition memory as well as the number and morphology of GFAP+ immunoreactive cells, in the hippocampus and frontal cortex of mice subjected to prolonged restraint stress. The results revealed that in addition to the mood and cognitive impairments, restraint stress induced a significant decrease in the number and arborization of GFAP+ cells in the brain of mice. Intranasal cotinine prevented these stress-derived symptoms and the morphological abnormalities GFAP+ cells in both of these brain regions which are critical to resilience to stress. The significance of these findings ...
Source: Experimental Neurology - Category: Neurology Authors: Tags: Exp Neurol Source Type: research

Related Links:

Authors: Pierce M, Hope HF, Kolade A, Gellatly J, Osam CS, Perchard R, Kosidou K, Dalman C, Morgan V, Di Prinzio P, Abel KM Abstract BACKGROUND: Children of parents with mental disorder face multiple challenges. AIMS: To summarise evidence about parental mental disorder and child physical health. METHOD: We searched seven databases for cohort or case-control studies quantifying associations between parental mental disorders (substance use, psychotic, mood, anxiety, obsessive-compulsive, post-traumatic stress and eating) and offspring physical health. Studies were excluded if: they reported perinatal outcomes only (
Source: The British Journal of Psychiatry for Mental Science - Category: Psychiatry Tags: Br J Psychiatry Source Type: research
According to a recently-published interview with John Torous, MD, MBI, Director of the Digital Psychiatry Division at the Department of Psychiatry at Beth Israel Deaconess Medical Center, there are seven great evidenced-based mental health apps you should consider. Evidence-based means they’ve met the minimum requirements by the U.S. Food and Drug Administration (FDA) or have at least one randomized clinical research study that supports their use and effectiveness. The recommendation for these evidence-based mental health apps comes in an interview with Dr. Torous found in the Oct. 2019 issue of The Carlat Psychiatr...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: General Medications Mental Health and Wellness Mindfulness Psychology Self-Help Technology evidence-based mental health apps Smartphone Source Type: blogs
More than 60 percent of CBD users were taking it for anxiety, according to a survey of 5,000 people. Does it help?
Source: NYT Health - Category: Consumer Health News Authors: Tags: Cannabis Foods and Products Anxiety and Stress Marijuana Mental Health and Disorders Drugs (Pharmaceuticals) Post-Traumatic Stress Disorder Sleep Addiction (Psychology) Research Clinical Trials Insomnia Depression (Mental) Hemp Source Type: news
Conclusions: Among male refugees living in precarious conditions in a Greek refugee camp, frequency of participation in an 8-week exercise and sport training program seemed to have the potential to positively impact refugees’ health. Due to the pre-experimental study design, our results must be interpreted with caution.
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
You're reading How to Prevent Your Anxiety from Rubbing Off On Your Child, originally posted on Pick the Brain | Motivation and Self Improvement. If you're enjoying this, please visit our site for more inspirational articles. Sometimes, it seems like our kids aren’t learning anything from us—but that’s simply not the case. Kids absorb all the information around them and learn by example. While that can be a good thing, it can also be a problem if you don’t want to pass on certain behaviors you’re modeling for them, like anxiety. If you’re struggling with anxiety, first remember that...
Source: PickTheBrain | Motivation and Self Improvement - Category: Consumer Health News Authors: Tags: depression family featured psychology self improvement Source Type: blogs
AbstractTo identify early life factors associated with posttraumatic stress disorder (PTSD), we investigated the association between childhood trauma and mental disorders withInternational Classification of Diseases (ICD)‐diagnosed past‐year PTSD in employed military and civilian men. Data were derived from the 2010 Australian Defence Force (ADF) Mental Health Prevalence and Wellbeing Study (N = 1,356) and the 2007 Australian Bureau of Statistics (ABS) National Survey of Mental Health and Wellbeing Study (N = 2,120) and analyzed using logistic regression and generalized structural equation modeling. After controll...
Source: Journal of Traumatic Stress - Category: Psychiatry & Psychology Authors: Tags: Research Article Source Type: research
CONCLUSIONS: The authors' findings provide insight regarding the mechanisms of spinal cord stimulation failure that resulted in total removal of the implanted system. The relationship between spinal cord stimulation failure and certain psychiatric disorders, such as PTSD, depression, and anxiety, is highlighted. Ultimately, this work may shed light on potential avenues to reduce morbidity and improve patient outcomes. PMID: 31585414 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery.Spine - Category: Neurosurgery Authors: Tags: J Neurosurg Spine Source Type: research
This article explores how women account for their experiences of pregnancy distress in light of cultural imperatives to be the perfect, happy mother. Our analysis is based on the accounts of 18 Australian women, interviewed during pregnancy on the basis of...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
CONCLUSIONS AND SCIENTIFIC SIGNIFICANCE: These conclusions are limited by a lack of well-controlled longitudinal studies. We suggest that future research be directed toward high-quality, prospective studies of cannabis in clinical populations with mood and ADs, in addition to controlled studies of cannabinoid constituents and pharmaceuticals in these populations. (Am J Addict 2019;00:00-00). PMID: 31577377 [PubMed - as supplied by publisher]
Source: American Journal on Addictions - Category: Addiction Authors: Tags: Am J Addict Source Type: research
ConclusionOur findings suggest that KRG has an antidepressant effect in rats subjected to SPS and may represent an effective use of traditional medicine for the treatment of PTSD.Graphical abstractKorean red ginseng administration significantly reversed the depression-like behavioral abnormalities in the forced swimming test. Biochemical alterations in the hippocampus including changes in levels of 5-HT were consistent with the behavioral results .
Source: Journal of Ginseng Research - Category: Complementary Medicine Source Type: research
More News: Anxiety | Brain | Depression | Men | Neurology | Post Traumatic Stress Disorder | Psychology