IL ‑22 expression is increased variedly in the initial phase, onset and chronic phase of a pristane‑induced arthritis rat model.

In conclusion, Th17 and Th22‑related factor expression varied in different disease progression phases and in different tissues in PIA rats. IL‑22 expression exhibited an increasing trend in the initial phase and the onset phase of arthritis and increased significantly with progression to chronic arthritis in the PIA rat model. It is thought that IL‑22 may serve an important role in the pathological process of PIA, particularly in the chronic fluctuation phase. Therefore, it may be a candidate molecule for the treatment of rheumatoid arthritis. PMID: 28627588 [PubMed - as supplied by publisher]
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research