Antitumor/Antifungal Celecoxib Derivative AR-12 is a Non-Nucleoside Inhibitor of the ANL-Family Adenylating Enzyme Acetyl CoA Synthetase.

ACS Infect Dis. 2016 Apr 8;2(4):268-280. Epub 2016 Feb 23.Koselny K1, Green J1, Favazzo L1, Glazier VE1, DiDone L1, Ransford S1, Krysan DJ1.AbstractAR-12/OSU-03012 is an antitumor celecoxib-derivative that has progressed to Phase I clinical trial as an anticancer agent and has activity against a number of infectious agents including fungi, bacteria and viruses. However, the mechanism of these activities has remained unclear.

Source: The Aspergillus Website - updates - June 20, 2017 Category: Respiratory Medicine Authors: GAtherton Source Type: news