Gut microbiota, metabolome and immune signatures in patients with uncomplicated diverticular disease

Conclusions
Patients with colonic diverticular disease show depletion of microbiota members with anti-inflammatory activity associated with mucosal macrophage infiltration. Metabolome profiles were linked to inflammatory pathways and gut neuromotor dysfunction and showed the ability to discriminate diverticular subgroups and controls. These data pave the way for further large-scale studies specifically aimed at identifying microbiota signatures with a potential diagnostic value in patients with diverticular disease.

Source: Gut - June 6, 2017 Category: Gastroenterology Authors: Barbara, G., Scaioli, E., Barbaro, M. R., Biagi, E., Laghi, L., Cremon, C., Marasco, G., Colecchia, A., Picone, G., Salfi, N., Capozzi, F., Brigidi, P., Festi, D. Tags: Gut microbiota Source Type: research