Structure, signaling and the drug discovery of the Ras oncogene protein.

Structure, signaling and the drug discovery of the Ras oncogene protein. BMB Rep. 2017 Jun 02;: Authors: Han CW, Jeong MS, Jang SB Abstract Mutations in Ras GTPase are among the most common genetic alterations in human cancers. Despite extensive research investigating Ras proteins, their functions still remain a challenge over a long period of time. The currently available data suggests that solving the outstanding issues regarding Ras could lead to development of effective drugs that could have a significant impact on cancer treatment. Developing a better understanding of their biochemical properties or modes of action, along with improvements in their pharmacologic profiles, clinical design and scheduling will enable the development of more effective therapies. PMID: 28571593 [PubMed - as supplied by publisher]
Source: BMB Reports - Category: Biochemistry Authors: Tags: BMB Rep Source Type: research