Oxytetracycline Inhibits Mucus Secretion and Inflammation in Human Airway Epithelial Cells

In this study, the effects of oxytetracycline on mucus secretion and inflammation were examined by PCR and ELISA in the human airway epithelial cell line NCI-H292. Oxytetracycline (10 μg/mL) significantly inhibited TNF-α-induced MUC5AC gene expression and MUC5AC protein levels in NCI-H292 cells. It also downregulatedIL-8and IL-1 β gene expression and IL-1 β protein levels. Our findings demonstrated that oxytetracycline suppressed mucus production and inflammation in human respiratory epithelial cells, providing further evidence for the usefulness of oxytetracycline for human airway inflammatory diseases.Chemotherapy 2017;62:301-306
Source: Chemotherapy - Category: Cancer & Oncology Source Type: research