Decreased frequency of peripheral blood CD8(+)CD25(+)FoxP3(+)regulatory T cells correlates with IL-33 levels in pre-eclampsia.

CONCLUSIONS: These findings suggest that the reduced CD8(+)CD25(+)Foxp3(+)Treg cells may play a role in the pathogenesis of PE. Abbreviations PE: pre-eclampsia; PBMCs: peripheral blood mononuclear cells; CTLA-4: cytotoxic T-lymphocyteantigen-4; APCs: antigen presenting cells; TGF-β: transforming growth factor-β; IL: interleukin; Treg: cells regulatory T cells; PBS: phosphate-buffered saline; Foxp3: forkhead Box protein 3; HELLPs: hemolysis, elevated liver enzyme and low platelet syndrome. PMID: 28541089 [PubMed - as supplied by publisher]
Source: Hypertension in Pregnancy - Category: OBGYN Tags: Hypertens Pregnancy Source Type: research