Atrial Fibrillation Genetic Risk and Ischemic Stroke Mechanisms [Clinical Sciences]

We examined associations between AF genetic risk and Trial of Org 10172 in Acute Stroke Treatment stroke subtypes in 2374 ambulatory individuals with ischemic stroke and 5175 without from the Wellcome Trust Case-Control Consortium 2 using logistic regression. We calculated AF genetic risk scores using single-nucleotide polymorphisms associated with AF in a previous independent analysis across a range of preselected significance thresholds.Results—There were 460 (19.4%) individuals with cardioembolic stroke, 498 (21.0%) with large vessel, 474 (20.0%) with small vessel, and 814 (32.3%) individuals with strokes of undetermined cause. Most AF genetic risk scores were associated with stroke, with the strongest association (P=6×10−4) attributed to scores of 944 single-nucleotide polymorphisms (each associated with AF at P
Source: Stroke - Category: Neurology Authors: Tags: Catheter Ablation and Implantable Cardioverter-Defibrillator, Epidemiology, Risk Factors, Genetics, Ischemic Stroke Original Contributions Source Type: research